PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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7UBO	Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor CCD-956 分子名称: Bromodomain testis-specific protein, DIMETHYL SULFOXIDE, N-[(2R)-1-(methylamino)-3-{1-[(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl]piperidin-4-yl}-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxamide 著者 Ta, H.M, Modukuri, R.K, Yu, Z, Tan, Z, Matzuk, M.M, Kim, C. 登録日 2022-03-15 公開日 2022-06-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc.Natl.Acad.Sci.USA, 119, 2022
6SWA	Mus musculus brain neocortex ribosome 60S bound to Ebp1 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Kraushar, M.L, Sprink, T. 登録日 2019-09-20 公開日 2020-09-30 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Mol.Cell, 81, 2021
3W35	Crystal structure of apo-type bacterial Vanadium-dependent chloroperoxidase 分子名称: NapH1 著者 Liscombe, D.K, Miyanaga, A, Fielding, E, Bernhardt, P, Li, A, Winter, J.M, Gilson, M.K, Noel, J.P, Moore, B.S. 登録日 2012-12-11 公開日 2013-12-11 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 2022
5CTT	Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex 分子名称: Importin subunit alpha-1, Squamous cell carcinoma antigen recognized by T-cells 3 著者 Park, J.K, Kim, E.E. 登録日 2015-07-24 公開日 2016-04-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Nucleic Acids Res., 44, 2016
5CTQ	Crystal structure of human SART3/TIP110 half-a TPR (HAT) domain 分子名称: Squamous cell carcinoma antigen recognized by T-cells 3 著者 Park, J.K, Kim, E.E. 登録日 2015-07-24 公開日 2016-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Nucleic Acids Res., 44, 2016
5CTR	Crystal structure of human SART3 HAT-C domain-human USP4 DUSP-UBL domain complex 分子名称: Squamous cell carcinoma antigen recognized by T-cells 3, Ubiquitin carboxyl-terminal hydrolase 4 著者 Park, J.K, Kim, E.E. 登録日 2015-07-24 公開日 2016-04-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.012 Å) 主引用文献 Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Nucleic Acids Res., 44, 2016
3W36	Crystal structure of holo-type bacterial Vanadium-dependent chloroperoxidase 分子名称: NapH1, VANADATE ION 著者 Liscombe, D.K, Miyanaga, A, Fielding, E, Bernhardt, P, Li, A, Winter, J.M, Gilson, M.K, Noel, J.P, Moore, B.S. 登録日 2012-12-11 公開日 2013-12-11 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 2022
4RF4	Crystal structure of ketoreductase from Lactobacillus kefir 分子名称: MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase 著者 Tang, Y, Tibrewal, N, Cascio, D. 登録日 2014-09-24 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.201 Å) 主引用文献 Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015
3PJN	The crystal structure of Tp34 bound to Zn(II) ion at pH 7.5 分子名称: 1,2-ETHANEDIOL, 34 kDa membrane antigen, SULFATE ION, ... 著者 Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V. 登録日 2010-11-10 公開日 2011-11-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Characterization of the Tp34 lipoprotein from Treponema pallidum suggests a role in transition metal homeostasis To be Published
4DIF	Structure of A1-type ketoreductase 分子名称: AmphB, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zheng, J, Keatinge-Clay, A.T. 登録日 2012-01-30 公開日 2013-02-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.521 Å) 主引用文献 Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity To be Published
1R7I	HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION 著者 Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. 登録日 2003-10-21 公開日 2003-11-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase. To be Published
4FHD	Spore photoproduct lyase complexed with dinucleoside spore photoproduct 分子名称: 1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-[[(5R)-1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-methyl-2,4-bis(oxidanylidene)-1,3-diazinan-5-yl]methyl]pyrimidine-2,4-dione, IRON/SULFUR CLUSTER, PYROPHOSPHATE 2-, ... 著者 Benjdia, A, Heil, K, Barends, T.R.M, Carell, T, Schlichting, I. 登録日 2012-06-06 公開日 2012-07-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Nucleic Acids Res., 40, 2012
1R31	HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA 分子名称: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... 著者 Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. 登録日 2003-09-30 公開日 2003-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase. To be Published
4RF3	Crystal Structure of ketoreductase from Lactobacillus kefir, mutant A94F 分子名称: GLYCEROL, MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase 著者 Tang, Y, Tibrewal, N, Cascio, D. 登録日 2014-09-24 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.694 Å) 主引用文献 Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015
8OOV	human NME-1 in complex with CoA 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A 著者 Gouge, J, Hristov, H.D. 登録日 2023-04-06 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1. Int J Mol Sci, 24, 2023
4FHF	Spore photoproduct lyase C140A mutant with dinucleoside spore photoproduct 分子名称: 1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-[[(5R)-1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-methyl-2,4-bis(oxidanylidene)-1,3-diazinan-5-yl]methyl]pyrimidine-2,4-dione, IRON/SULFUR CLUSTER, PYROPHOSPHATE 2-, ... 著者 Benjdia, A, Heil, K, Barends, T.R.M, Carell, T, Schlichting, I. 登録日 2012-06-06 公開日 2012-07-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Nucleic Acids Res., 40, 2012
7Z24	Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine 分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (38-mer), Reverse transcriptase/ribonuclease H 著者 Singh, A.K, Das, K. 登録日 2022-02-25 公開日 2022-07-20 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119, 2022
7Z29	Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine 分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (38-MER), Reverse transcriptase/ribonuclease H, ... 著者 Singh, A.K, Das, K. 登録日 2022-02-26 公開日 2022-07-20 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119, 2022
4RXQ	The structure of GTP-dUTP-bound SAMHD1 分子名称: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. 登録日 2014-12-11 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
4RF5	Crystal structure of ketoreductase from Lactobacillus kefir, E145S mutant 分子名称: GLYCEROL, MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase 著者 Tang, Y, Tibrewal, N, Cascio, D. 登録日 2014-09-24 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.596 Å) 主引用文献 Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015
4RXR	The structure of GTP-dCTP-bound SAMHD1 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. 登録日 2014-12-11 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.117 Å) 主引用文献 The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
4RZ9	Pre-mRNA-splicing factor 38A AS 1-179 分子名称: Pre-mRNA-splicing factor 38A 著者 Schuetze, T, Weber, G, Wahl, M.C. 登録日 2014-12-19 公開日 2015-12-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 The N-terminal domain of the unusual SR protein hPrp38 is an interaction hub in the spliceosome To be Published
4TU5	Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1062) 分子名称: 6-ethyl-5-{(3S)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Reeve, S.M, Anderson, A.C. 登録日 2014-06-23 公開日 2015-07-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.161 Å) 主引用文献 Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus. J.Am.Chem.Soc., 137, 2015
1BTO	HORSE LIVER ALCOHOL DEHYDROGENASE COMPLEXED TO NADH AND (1S,3R)3-BUTYLTHIOLANE 1-OXIDE 分子名称: 3-BUTYLTHIOLANE 1-OXIDE, LIVER ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Ramaswamy, S, Plapp, B.V. 登録日 1996-11-08 公開日 1997-04-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides. Biochemistry, 36, 1997
4RF2	Crystal structure of NADP+ bound ketoreductase from Lactobacillus kefir 分子名称: MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH dependent R-specific alcohol dehydrogenase 著者 Tang, Y, Tibrewal, N, Cascio, D. 登録日 2014-09-24 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.089 Å) 主引用文献 Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015

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