7UBO

Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor CCD-956

Summary for 7UBO

Entry DOI	10.2210/pdb7ubo/pdb
Descriptor	Bromodomain testis-specific protein, N-[(2R)-1-(methylamino)-3-{1-[(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl]piperidin-4-yl}-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	inhibitor, regulator, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	54925.73
Authors	Ta, H.M.,Modukuri, R.K.,Yu, Z.,Tan, Z.,Matzuk, M.M.,Kim, C. (deposition date: 2022-03-15, release date: 2022-06-08, Last modification date: 2023-10-18)
Primary citation	Modukuri, R.K.,Yu, Z.,Tan, Z.,Ta, H.M.,Ucisik, M.N.,Jin, Z.,Anglin, J.L.,Sharma, K.L.,Nyshadham, P.,Li, F.,Riehle, K.,Faver, J.C.,Duong, K.,Nagarajan, S.,Simmons, N.,Palmer, S.S.,Teng, M.,Young, D.W.,Yi, J.S.,Kim, C.,Matzuk, M.M. Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc.Natl.Acad.Sci.USA, 119:e2122506119-e2122506119, 2022 Cited by PubMed: 35622893 DOI: 10.1073/pnas.2122506119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation