6MLC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mlc by Molmil](/molmil-images/mine/6mlc) | PHD6 domain of MLL3 in complex with histone H4 | 分子名称: | GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ... | 著者 | Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-27 | 公開日 | 2018-10-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nat Commun, 10, 2019
|
|
7PCE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pce by Molmil](/molmil-images/mine/7pce) | BurG (apo): Biosynthesis of cyclopropanol rings in bacterial toxins | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Ketol-acid reductoisomerase, PHOSPHATE ION | 著者 | Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. | 登録日 | 2021-08-03 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat.Chem., 14, 2022
|
|
6MT3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mt3 by Molmil](/molmil-images/mine/6mt3) | |
6MTL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mtl by Molmil](/molmil-images/mine/6mtl) | |
6MTO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mto by Molmil](/molmil-images/mine/6mto) | Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold | 分子名称: | Antibody VRC42.01 Fab heavy chain, Antibody VRC42.01 Fab light chain, VRC42 epitope T117-F scaffold | 著者 | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D. | 登録日 | 2018-10-21 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.634 Å) | 主引用文献 | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
|
|
6MTR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mtr by Molmil](/molmil-images/mine/6mtr) | Crystal structure of VRC43.01 Fab | 分子名称: | Antibody VRC43.01 Fab heavy chain, Antibody VRC43.01 Fab light chain | 著者 | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D. | 登録日 | 2018-10-21 | 公開日 | 2019-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
|
|
6MP0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mp0 by Molmil](/molmil-images/mine/6mp0) | Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with the TRP1-M9 peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TRP1-M9 peptide, Beta-2-microglobulin,H-2 class I histocompatibility antigen, ... | 著者 | Clancy-Thompson, E, Devlin, C.A, Birnbaum, M.E, Dougan, S.K. | 登録日 | 2018-10-05 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+T Cell-Effector Responses. Cancer Immunol Res, 6, 2018
|
|
8IRZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8irz by Molmil](/molmil-images/mine/8irz) | Carbon Sulfoxide lyase | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Probable hercynylcysteine sulfoxide lyase | 著者 | Gong, W.M, Wei, L.L, Liu, L. | 登録日 | 2023-03-20 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE. J.Biol.Chem., 300, 2024
|
|
6MPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mph by Molmil](/molmil-images/mine/6mph) | Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DF1W-a.01 Light chain, ... | 著者 | Acharya, P, Xu, K, Kwong, P.D. | 登録日 | 2018-10-06 | 公開日 | 2019-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
|
|
8J72
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j72 by Molmil](/molmil-images/mine/8j72) | Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1 | 分子名称: | E3 ubiquitin-protein ligase TRIM71, lncRNA Trincr1 | 著者 | Shi, F.D, Zhang, K, Che, S.Y, Zhi, S.X, Yang, N. | 登録日 | 2023-04-27 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein. Sci Bull (Beijing), 69, 2024
|
|
7PZX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pzx by Molmil](/molmil-images/mine/7pzx) | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | 分子名称: | (2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((4-((4-((S)-2-hydroxy-1-methoxyethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | 登録日 | 2021-10-13 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published
|
|
5QDB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5qdb by Molmil](/molmil-images/mine/5qdb) | Crystal structure of BACE complex with BMC002 | 分子名称: | (3S,14R,16S)-16-[(1R)-1-hydroxy-2-{[3-(1-methylethyl)benzyl]amino}ethyl]-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5- dione, Beta-secretase 1 | 著者 | Rondeau, J.M, Shao, C, Yang, H, Burley, S.K. | 登録日 | 2017-12-01 | 公開日 | 2020-06-03 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | D3R grand challenge 4: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies. J.Comput.Aided Mol.Des., 34, 2020
|
|
8IS0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8is0 by Molmil](/molmil-images/mine/8is0) | Carbon Sulfoxide lyase - Y106F | 分子名称: | 2-AMINO-ACRYLIC ACID, PYRIDOXAL-5'-PHOSPHATE, Probable hercynylcysteine sulfoxide lyase | 著者 | Gong, W.M, Wei, L.L, Liu, L. | 登録日 | 2023-03-20 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE. J.Biol.Chem., 300, 2024
|
|
5C3T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c3t by Molmil](/molmil-images/mine/5c3t) | |
5COE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5coe by Molmil](/molmil-images/mine/5coe) | The structure of the NK1 fragment of HGF/SF complexed with HEPES | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Ascher, D.B, Chirgadze, D.Y, Blundell, T.L, Gherardi, E. | 登録日 | 2015-07-20 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6, 2015
|
|
5BYY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5byy by Molmil](/molmil-images/mine/5byy) | ERK5 IN COMPLEX WITH SMALL MOLECULE | 分子名称: | 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Mitogen-activated protein kinase 7 | 著者 | Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D. | 登録日 | 2015-06-11 | 公開日 | 2016-05-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site. Acta Crystallogr D Struct Biol, 72, 2016
|
|
8IRY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8iry by Molmil](/molmil-images/mine/8iry) | Carbon Sulfoxide lyase | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, PYRUVIC ACID, Probable hercynylcysteine sulfoxide lyase | 著者 | Gong, W.M, Wei, L.L, Liu, L. | 登録日 | 2023-03-20 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE. J.Biol.Chem., 300, 2024
|
|
6MUD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mud by Molmil](/molmil-images/mine/6mud) | |
7PTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pti by Molmil](/molmil-images/mine/7pti) | |
5CEY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cey by Molmil](/molmil-images/mine/5cey) | |
5CFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cfc by Molmil](/molmil-images/mine/5cfc) | |
6MUG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mug by Molmil](/molmil-images/mine/6mug) | |
8IYU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8iyu by Molmil](/molmil-images/mine/8iyu) | |
8J59
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j59 by Molmil](/molmil-images/mine/8j59) | |
6N0M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6n0m by Molmil](/molmil-images/mine/6n0m) | |