6MUD

Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin

Summary for 6MUD

• Entry DOI: 10.2210/pdb6mud/pdb
• Descriptor: Calmodulin-1, Sodium channel protein type 5 subunit alpha, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: voltage-gated ion channel, transport protein, ef-hand domain, calcium binding-transport protein complex, calcium binding/transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 33270.51

Authors

Gardill, B.R.,Tung, C.C.,Van Petegem, F. (deposition date: 2018-10-23, release date: 2019-05-08, Last modification date: 2024-03-13)

• Primary citation: Gardill, B.R.,Rivera-Acevedo, R.E.,Tung, C.C.,Van Petegem, F.; Crystal structures of Ca2+-calmodulin bound to NaVC-terminal regions suggest role for EF-hand domain in binding and inactivation.; Proc.Natl.Acad.Sci.USA, 116:10763-10772, 2019; PubMed: 31072926; DOI: 10.1073/pnas.1818618116

Experimental method

X-RAY DIFFRACTION (2.69 Å)