PDB: 5578 件ウェブページステータス検索Chemie searchBIRD

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6BD2	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
3W8H	Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25 分子名称: Programmed cell death protein 10, SULFATE ION, Serine/threonine-protein kinase 25 著者 Xu, X, Wang, D.C, Ding, J. 登録日 2013-03-13 公開日 2013-07-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III. Structure, 21, 2013
6ZB3	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK620 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, PENTAETHYLENE GLYCOL, ... 著者 Chung, C. 登録日 2020-06-06 公開日 2020-08-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.419 Å) 主引用文献 The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J.Med.Chem., 63, 2020
6I18	CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176 分子名称: 1,2-ETHANEDIOL, 5-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-1-piperidin-4-yl-~{N}-pyridin-4-yl-pyrazolo[4,3-c]pyridine-7-carboxamide, ACETATE ION, ... 著者 Schuettelkopf, A.W. 登録日 2018-10-27 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
6ERH	Complex of XLF and heterodimer Ku bound to DNA 分子名称: DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ... 著者 Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. 登録日 2017-10-18 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat. Struct. Mol. Biol., 25, 2018
8ITV	KL2.1 in complex with CRM1-Ran-RanBP1 分子名称: (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoic acid, ACETATE ION, CHLORIDE ION, ... 著者 Sun, Q, Jian, L. 登録日 2023-03-23 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 KL2.1 in complex with CRM1-Ran-RanBP1 To Be Published
3WE2	Structure of BLM RQC domain bound to a phosphate ion 分子名称: ACETATE ION, Bloom syndrome protein, PHOSPHATE ION 著者 Kim, S.Y, Hakoshima, T, Kitano, K. 登録日 2013-06-28 公開日 2013-11-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of the RecQ C-terminal Domain of Human Bloom Syndrome Protein Sci Rep, 3, 2013
7QBW	Human Cyclophilin A double mutant C52AK125C 分子名称: GLYCEROL, Peptidyl-prolyl cis-trans isomerase A 著者 Fischer, L, Buratto, J, Langlois d'Estaintot, B. 登録日 2021-11-19 公開日 2022-11-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Human Cyclophilin A double mutant C52AK125C To Be Published
7QDL	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 with I-BET567 分子名称: (2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Chung, C. 登録日 2021-11-27 公開日 2022-12-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. J.Med.Chem., 65, 2022
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide 分子名称: 14-3-3 protein epsilon, SER-ILE-SEP-ARG 著者 Akutsu, M, Wagner, S.A, Beli, P. 登録日 2017-09-19 公開日 2018-02-14 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
3WPQ	crystal structure of the GAP domain of MgcRacGAP(S387A) 分子名称: Rac GTPase-activating protein 1 著者 Murayama, K, Kato-Murayama, M, Shirouzu, M, Kitamura, T, Yokoyama, S. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 crystal structure of the GAP domain of MgcRacGAP To be Published
6BAG	Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one 分子名称: (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl)amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-12 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
6BB0	Lactate Dehydrogenase in complex with inhibitor (R)-3-((2-chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
6IGX	Crystal structure of human CAP-G in complex with CAP-H 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Condensin complex subunit 2, Condensin complex subunit 3 著者 Hara, K, Migita, T, Shimizu, K, Hashimoto, H. 登録日 2018-09-26 公開日 2019-03-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. Embo Rep., 20, 2019
6ERF	Complex of APLF factor and Ku heterodimer bound to DNA 分子名称: Aprataxin and PNK-like factor, DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ... 著者 Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. 登録日 2017-10-18 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat.Struct.Mol.Biol., 25, 2018
3W3Z	Crystal structure of Kap121p bound to RanGTP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-3, ... 著者 Kobayashi, J, Matsuura, Y. 登録日 2012-12-28 公開日 2013-04-10 最終更新日 2014-01-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p. J.Mol.Biol., 425, 2013
2IW5	Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase 分子名称: AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H. 登録日 2006-06-26 公開日 2006-08-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase Mol.Cell, 23, 2006
7QNZ	human Lig1-DNA-PCNA complex reconstituted in absence of ATP 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.58 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
3WE3	Structure of BLM RQC domain bound to an arsenate ion 分子名称: ACETATE ION, ARSENATE, Bloom syndrome protein 著者 Kim, S.Y, Hakoshima, T, Kitano, K. 登録日 2013-06-28 公開日 2013-11-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the RecQ C-terminal Domain of Human Bloom Syndrome Protein Sci Rep, 3, 2013
6YXO	Structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1 分子名称: SWI/SNF complex subunit SMARCC1 著者 Allen, M.D, Bycroft, M, Zinzalla, G. 登録日 2020-05-03 公開日 2021-04-21 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. Commun Biol, 4, 2021
6BAZ	Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one 分子名称: (3S,6S)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-6-(thiophen-3-yl)piperidine-2,4-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
6BCY	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360 分子名称: 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6BD1	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366 分子名称: 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, Insulin receptor substrate protein of 53 kDa, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6YXP	Higher resolution structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1 分子名称: SWI/SNF complex subunit SMARCC1 著者 Allen, M.D, Bycroft, M, Zinzalla, G. 登録日 2020-05-03 公開日 2021-04-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. Commun Biol, 4, 2021
6BAD	Lactate Dehydrogenase in complex with inhibitor (R)-3-((2-chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6R)-3-[(2-chlorophenyl)sulfanyl]-6-{3-[(4-fluorophenyl)amino]phenyl}-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-12 公開日 2018-10-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published

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