PDB: 3084 件ウェブページステータス検索Chemie searchBIRD

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1WUG	complex structure of PCAF bromodomain with small chemical ligand NP1 分子名称: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE 著者 Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. 登録日 2004-12-07 公開日 2005-08-16 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
1WUM	Complex structure of PCAF bromodomain with small chemical ligand NP2 分子名称: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE 著者 Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. 登録日 2004-12-08 公開日 2005-08-16 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
5QJ1	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide 分子名称: 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, RNA-dependent RNA polymerase, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
5QJ0	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide 分子名称: 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, NONAETHYLENE GLYCOL, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
5X0W	Molecular mechanism for the binding between Sharpin and HOIP 分子名称: E3 ubiquitin-protein ligase RNF31, Sharpin 著者 Liu, J, Li, F, Cheng, X, Pan, L. 登録日 2017-01-23 公開日 2017-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly Cell Rep, 21, 2017
5TE4	Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhou, T, Kwong, P.D. 登録日 2016-09-20 公開日 2016-11-23 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45, 2016
3KSB	Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (re-sealed form) 分子名称: 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*TP*GP*AP*CP*TP*AP*TP*GP*CP*AP*CP*GP*TP*AP*AP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*TP*TP*A*CP*GP*TP*GP*CP*AP*TP*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*GP*AP*CP*CP*TP*TP*GP*GP*T)-3', DNA topoisomerase 4 subunit A, ... 著者 Laponogov, I, Pan, X.-S, Veselkov, D.A, McAuley, K.E, Fisher, L.M, Sanderson, M.R. 登録日 2009-11-21 公開日 2010-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases Plos One, 5, 2010
3KSA	Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (cleaved form) 分子名称: 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3', 5'-D(*CP*TP*GP*TP*TP*TP*TP*A*CP*GP*TP*GP*CP*AP*T)-3', 5'-D(P*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*GP*AP*CP*CP*TP*TP*GP*GP*T)-3', ... 著者 Laponogov, I, Pan, X.-S, Veselkov, D.A, McAuley, K.E, Fisher, L.M, Sanderson, M.R. 登録日 2009-11-21 公開日 2010-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases Plos One, 5, 2010
4WRS	Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor. 分子名称: 3-{6-[(4R)-6-azaspiro[2.5]oct-4-yloxy]pyrazin-2-yl}-5-(2,6-difluorophenyl)-1H-indazole, GLYCEROL, Serine/threonine-protein kinase pim-1 著者 Mohr, C. 登録日 2014-10-25 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
7OBN	Structural investigations of a new L3 DNA ligase: structure-function analysis 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), DNA ligase, ... 著者 Leiros, H.-K.S, Williamson, A. 登録日 2021-04-23 公開日 2022-02-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase. Sci Rep, 11, 2021
2FNP	Crystal structure of SarA 分子名称: Staphylococcal accessory regulator A 著者 Liu, Y, Manna, A.C, Pan, C.H, Cheung, A.L, Zhang, G. 登録日 2006-01-11 公開日 2006-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc.Natl.Acad.Sci.Usa, 103, 2006
2G91	Crystal Structure Analysis of the an RNA nonamer r(GGUGCGC)d(BrC)r(C) 分子名称: 5'-R(*GP*GP*UP*GP*CP*GP*CP*(CBR)P*C-3', MAGNESIUM ION 著者 Shi, K, Pan, B, Sundaralingam, M. 登録日 2006-03-04 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure of an RNA nonamer r(GGUGCGC)d(BrC)r(C) at 1.5 A resolution To be Published
1EV0	SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN 分子名称: MINE 著者 King, G.F, Maciejewski, M.W, Pan, B, Mullen, G.P. 登録日 2000-04-19 公開日 2000-11-01 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structural basis for the topological specificity function of MinE. Nat.Struct.Biol., 7, 2000
3KE0	Crystal structure of N370S Glucocerebrosidase at acidic pH. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wei, R.R, Boucher, S, Pan, C.Q, Edmunds, T. 登録日 2009-10-23 公開日 2010-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of Glucocerebrosidase Containing the N370S Mutation, Implications for Chaperon Therapy To be Published
4RPV	co-crystal structure of Pim1 with compound 3 分子名称: (3S)-1-{6-[5-(2,6-difluorophenyl)-2H-indazol-3-yl]pyrazin-2-yl}piperidin-3-amine, Serine/threonine-protein kinase pim-1 著者 Huang, X. 登録日 2014-10-31 公開日 2015-02-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
2ZNN	Human PPAR alpha ligand binding domain in complex with a synthetic agonist TIPP703 分子名称: (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid, Peroxisome proliferator-activated receptor alpha 著者 Oyama, T, Toyota, K, Kasuga, J, Miyachi, H, Morikawa, K. 登録日 2008-04-30 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65, 2009
2ZNP	Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP204 分子名称: (2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]benzyl}butanoic acid, Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside 著者 Oyama, T, Hirakawa, Y, Nagasawa, N, Miyachi, H, Morikawa, K. 登録日 2008-04-30 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65, 2009
2ZNO	Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703 分子名称: (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Oyama, T, Waku, T, Kasuga, J, Miyachi, H, Morikawa, K. 登録日 2008-04-30 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65, 2009
2ZNQ	Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP401 分子名称: (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid, Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside 著者 Oyama, T, Hirakawa, Y, Nagasawa, N, Miyachi, H, Morikawa, K. 登録日 2008-04-30 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65, 2009
6OLD	CSP1-cyc(Dap6E10) 分子名称: Competence-stimulating peptide type 1 著者 Yang, Y. 登録日 2019-04-16 公開日 2020-01-08 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity inStreptococcus pneumoniae. Proc.Natl.Acad.Sci.USA, 117, 2020
4XKL	Crystal structure of NDP52 ZF2 in complex with mono-ubiquitin 分子名称: ACETATE ION, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... 著者 Xie, X, Li, F, Wang, Y, Lin, Z, Chen, X, Liu, J, Pan, L. 登録日 2015-01-12 公開日 2015-11-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2 Autophagy, 11, 2015
4XBS	2-deoxyribose-5-phosphate aldolase mutant - E78K 分子名称: Deoxyribose-phosphate aldolase 著者 Jiao, X.-C, Pan, J, Xu, G.-C, Kong, X.-D, Chen, Q, Zhang, Z.-J, Xu, J.-H. 登録日 2014-12-17 公開日 2015-11-04 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis Catalysis Science And Technology, 5, 2015
4XBK	2-deoxyribose-5-phosphate aldolase from Lactobacillus brevis 分子名称: ACETIC ACID, Deoxyribose-phosphate aldolase 著者 Jiao, X.-C, Pan, J, Xu, G.-C, Kong, X.-D, Chen, Q, Zhang, Z.-J, Xu, J.-H. 登録日 2014-12-17 公開日 2015-11-04 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis Catalysis Science And Technology, 5, 2015
4XMK	Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 in complex with JR-FL V3 peptide 分子名称: HIV-1 JR-FL gp120 V3 peptide, Heavy chain of HIV-1 gp120 V3-specific human monoclonal antibody 2424, Light chain of HIV-1 gp120 V3-specific human monoclonal antibody 2424 著者 Kong, X.-P, Pan, R. 登録日 2015-01-14 公開日 2015-07-08 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (3.179 Å) 主引用文献 Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL. J.Virol., 89, 2015
1CU4	CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE 分子名称: FAB HEAVY CHAIN, FAB LIGHT CHAIN, RECOGNITION PEPTIDE 著者 Kanyo, Z.F, Pan, K.M, Williamson, R.A, Burton, D.R, Prusiner, S.B, Fletterick, R.J, Cohen, F.E. 登録日 1999-08-20 公開日 2000-04-17 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J.Mol.Biol., 293, 1999

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