PDB: 599 件ウェブページステータス検索Chemie searchBIRD

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5HID	BRAF Kinase domain b3aC loop deletion mutant in complex with AZ628 分子名称: 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide, DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase B-raf 著者 Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. 登録日 2016-01-11 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5HJB	AF9 YEATS in complex with histone H3 Crotonylation at K9 分子名称: Protein AF-9, peptide of Histone H3.1 著者 Li, Y.Y, Zhao, D, Guan, H.P, Li, H.T. 登録日 2016-01-12 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain Mol.Cell, 62, 2016
4PP7	Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase 分子名称: N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf 著者 Wenglowsky, S, Ren, L, Grina, J, Hansen, J.D, Laird, E.R, Moreno, D, Dinkel, V, Gloor, S.L, Hastings, G, Rana, S, Rasor, K, Sturgis, H.L, Voegtli, W.C, Vigers, G.P.A, Willis, B, Mathieu, S, Rudolph, J. 登録日 2014-02-26 公開日 2014-04-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 24, 2014
5H6R	Crystal structure of LSD1-CoREST in complex with peptide 13 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... 著者 Kkuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. 登録日 2016-11-14 公開日 2017-04-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25, 2017
5HI2	BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib 分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Serine/threonine-protein kinase B-raf 著者 Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. 登録日 2016-01-11 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.512 Å) 主引用文献 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
2RI7	Crystal structure of PHD finger-linker-bromodomain Y17E mutant from human BPTF in the H3(1-9)K4ME2 bound state 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Nucleosome-remodeling factor subunit BPTF, ... 著者 Li, H, Patel, D.J. 登録日 2007-10-10 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
5HIE	BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib 分子名称: Dabrafenib, Serine/threonine-protein kinase B-raf 著者 Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. 登録日 2016-01-11 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5H6Q	Crystal structure of LSD1-CoREST in complex with peptide 11 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... 著者 Kikuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. 登録日 2016-11-14 公開日 2017-04-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25, 2017
4QBQ	Crystal structure of DNMT3a ADD domain bound to H3 peptide 分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone H3, ZINC ION 著者 Li, H, Patel, D.J. 登録日 2014-05-08 公開日 2015-05-13 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs To be Published
2RR4	Complex structure of the zf-CW domain and the H3K4me3 peptide 分子名称: Histone H3, ZINC ION, Zinc finger CW-type PWWP domain protein 1 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2010-03-24 公開日 2010-09-15 最終更新日 2011-07-13 実験手法 SOLUTION NMR 主引用文献 Structural insight into the zinc finger CW domain as a histone modification reader Structure, 18, 2010
2RVN	Solution structure of the chromodomain of HP1a with the phosphorylated N-terminal tail complexed with H3K9me3 peptide 分子名称: 18-mer peptide of Histone H3, Chromobox protein homolog 5 著者 Kawaguchi, A, Nishimura, Y. 登録日 2015-12-18 公開日 2016-03-16 実験手法 SOLUTION NMR 主引用文献 Extended string-like binding of the phosphorylated HP1 alpha N-terminal tail to the lysine 9-methylated histone H3 tail Sci Rep, 6, 2016
2RS9	Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide 分子名称: Acetylated lysine 5 of peptide from Histone H4, Peregrin 著者 Qin, X, Nagashima, T, Umehara, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-12-08 公開日 2012-12-12 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Site-specific histone recognition by the bromodomain of Brpf1 and the role in MOZ/MORF histone acetyltransferase complexes To be Published
5I3L	DPF3b in complex with H3K14ac peptide 分子名称: 1,2-ETHANEDIOL, H3K14ac peptide, SODIUM ION, ... 著者 Tempel, W, Liu, Y, Walker, J.R, Zhao, A, Qin, S, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-02-10 公開日 2016-02-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of DPF3b in complex with an acetylated histone peptide. J.Struct.Biol., 195, 2016
2UXN	Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation 分子名称: CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Yang, M, Culhane, J.C, Szewczuk, L.M, Gocke, C.B, Brautigam, C.A, Tomchick, D.R, Machius, M, Cole, P.A, Yu, H. 登録日 2007-03-28 公開日 2007-05-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation. Nat.Struct.Mol.Biol., 14, 2007
2V83	Crystal structure of RAG2-PHD finger in complex with H3K4me3 peptide 分子名称: HISTONE H3, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
4QEO	crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH 分子名称: DNA 5'-ACTGATGAGTACCAT-3', DNA 5'-GGTACT(5CM)ATCAGTAT-3', Histone H3, ... 著者 Du, J, Li, S, Patel, D.J. 登録日 2014-05-17 公開日 2014-07-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell, 55, 2014
2V89	Crystal structure of RAG2-PHD finger in complex with H3K4me3 peptide at 1.1A resolution 分子名称: HISTONE H3, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-03 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Rag2 Phd Finger Couples Histone H3 Lysine 4 Trimethylation with V(D)J Recombination. Nature, 450, 2007
2V88	Crystal structure of RAG2-PHD finger in complex with H3R2me2sK4me2 peptide 分子名称: H3R2ME2SK4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-03 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
2V86	Crystal structure of RAG2-PHD finger in complex with H3R2me2aK4me3 peptide 分子名称: H3R2ME2AK4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
2V1D	Structural basis of LSD1-CoREST selectivity in histone H3 recognition 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, HISTONE H3.1T, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Forneris, F, Binda, C, Adamo, A, Battaglioli, E, Mattevi, A. 登録日 2007-05-23 公開日 2007-05-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Basis of Lsd1-Corest Selectivity in Histone H3 Recognition. J.Biol.Chem., 282, 2007
2V85	Crystal structure of RAG2-PHD finger in complex with H3R2me1K4me3 peptide 分子名称: H3R2ME1K4ME3 PEPTIDE, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
2UWD	Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs 分子名称: 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, ... 著者 Sharp, S.Y, Prodromou, C, Boxall, K, Powers, M.V, Holmes, J.L, Box, G, Matthews, T.P, Cheung, K.M, Kalusa, A, James, K, Hayes, A, Hardcastle, A, Dymock, B, Brough, P.A, Barril, X, Cansfield, J.E, Wright, L.M, Surgenor, A, Foloppe, N, Aherne, W, Pearl, L, Jones, K, McDonald, E, Raynaud, F, Eccles, S, Drysdale, M, Workman, P. 登録日 2007-03-20 公開日 2007-04-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol. Cancer Ther., 6, 2007
2V87	Crystal structure of RAG2-PHD finger in complex with H3R2me2sK4me3 peptide 分子名称: HISTONE H3.2, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
4QYL	Crystal Structure of the human BRPF1 bromodomain in complex with a histone H2AK5ac peptide 分子名称: Histone H2A type 1, Peregrin, SULFATE ION 著者 Lubula, M.Y, Glass, K.C. 登録日 2014-07-24 公開日 2014-09-24 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. Febs Lett., 588, 2014
2VNF	MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, HISTONE H3, ... 著者 Palacios, A, Munoz, I.G, Pantoja-Uceda, D, Marcaida, M.J, Torres, D, Martin-Garcia, J.M, Luque, I, Montoya, G, Blanco, F.J. 登録日 2008-02-04 公開日 2008-04-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Molecular Basis of Histone H3K4Me3 Recognition by Ing4 J.Biol.Chem., 283, 2008

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