4QYL
Crystal Structure of the human BRPF1 bromodomain in complex with a histone H2AK5ac peptide
Summary for 4QYL
Entry DOI | 10.2210/pdb4qyl/pdb |
Related | 4QYD |
Descriptor | Peregrin, Histone H2A type 1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | bromodomain-phd finger protein 1 (brpf1), histone acetyltransferase (hat), monocytic leukemia zinc-finger (moz), epigenetics, chromatin reader, bromodomain, histone post-transcriptional modification (ptm) reader domain, acetyllysine, nucleus, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P55201 P0C0S8 |
Total number of polymer chains | 8 |
Total formula weight | 60136.44 |
Authors | Lubula, M.Y.,Glass, K.C. (deposition date: 2014-07-24, release date: 2014-09-24, Last modification date: 2023-12-06) |
Primary citation | Lubula, M.Y.,Eckenroth, B.E.,Carlson, S.,Poplawski, A.,Chruszcz, M.,Glass, K.C. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. Febs Lett., 588:3844-3854, 2014 Cited by PubMed: 25281266DOI: 10.1016/j.febslet.2014.09.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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