4QYL
Crystal Structure of the human BRPF1 bromodomain in complex with a histone H2AK5ac peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | ARG91 |
| A | ARG95 |
| A | HOH314 |
| A | HOH316 |
| D | ARG109 |
| D | GLN110 |
| D | LYS113 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 201 |
| Chain | Residue |
| B | HOH339 |
| B | HOH427 |
| B | HOH484 |
| C | ARG109 |
| C | GLN110 |
| C | LYS113 |
| C | HOH321 |
| B | ARG91 |
| B | ARG95 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 201 |
| Chain | Residue |
| B | ARG109 |
| B | GLN110 |
| B | LYS113 |
| B | HOH304 |
| C | ARG91 |
| C | ARG95 |
| C | HOH334 |
| C | HOH463 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 201 |
| Chain | Residue |
| A | ARG109 |
| A | GLN110 |
| A | LYS113 |
| A | HOH309 |
| D | ARG91 |
| D | ARG95 |
| D | HOH360 |
| D | HOH422 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. GniFsepvPlsevp..DYLdhIkkpMdfftMkqnleayr..Ylnfddfeedfnl.IvsNClkY |
| Chain | Residue | Details |
| A | GLY25-TYR82 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 416 |
| Details | Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by RPS6KA5","evidences":[{"source":"PubMed","id":"11709551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15010469","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P22752","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
