2FOQ
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2FOU
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2FOV
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2FOY
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![BU of 2foy by Molmil](/molmil-images/mine/2foy) | Human Carbonic Anhydrase I complexed with a two-prong inhibitor | 分子名称: | Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER | 著者 | Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W. | 登録日 | 2006-01-14 | 公開日 | 2006-04-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2FNM
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![BU of 2fnm by Molmil](/molmil-images/mine/2fnm) | Activation of human carbonic anhdyrase II by exogenous proton donors | 分子名称: | ZINC ION, carbonic anhydrase 2 | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
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2FMZ
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![BU of 2fmz by Molmil](/molmil-images/mine/2fmz) | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine. | 分子名称: | Carbonic anhydrase 2, D-PHENYLALANINE, MERCURY (II) ION, ... | 著者 | Temperini, C, Scozzafava, A, Vullo, D, Supuran, C.T. | 登録日 | 2006-01-10 | 公開日 | 2006-05-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design. J.Med.Chem., 49, 2006
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2FNK
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![BU of 2fnk by Molmil](/molmil-images/mine/2fnk) | Activation of Human Carbonic Anhydrase II by exogenous proton donors | 分子名称: | Carbonic anhydrase 2, ZINC ION | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
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2FOS
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2FW4
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![BU of 2fw4 by Molmil](/molmil-images/mine/2fw4) | Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine. | 分子名称: | Carbonic anhydrase 1, HISTIDINE, ZINC ION | 著者 | Temperini, C, Scozzafava, A, Supuran, C.T. | 登録日 | 2006-02-01 | 公開日 | 2006-08-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I. Bioorg.Med.Chem.Lett., 16, 2006
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2FNN
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![BU of 2fnn by Molmil](/molmil-images/mine/2fnn) | Activation of human carbonic anhydrase II by exogenous proton donors | 分子名称: | 4-METHYLIMIDAZOLE, Carbonic Anhydrase 2, ZINC ION | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
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2GD8
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![BU of 2gd8 by Molmil](/molmil-images/mine/2gd8) | Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate | 分子名称: | (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE, CHLORIDE ION, Carbonic anhydrase 2, ... | 著者 | De Simone, G, Di Fiore, A. | 登録日 | 2006-03-15 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J.Med.Chem., 49, 2006
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2GEH
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![BU of 2geh by Molmil](/molmil-images/mine/2geh) | N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors | 分子名称: | Carbonic anhydrase 2, MERCURY (II) ION, N-HYDROXYUREA, ... | 著者 | Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T. | 登録日 | 2006-03-20 | 公開日 | 2006-06-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-Hydroxyurea-A versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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7POM
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7PUU
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![BU of 7puu by Molmil](/molmil-images/mine/7puu) | Crystal structure of carbonic anhydrase XII with methyl 4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, Carbonic anhydrase 12, ZINC ION, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-09-30 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7Q0D
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![BU of 7q0d by Molmil](/molmil-images/mine/7q0d) | Human carbonic anhydrase I in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Carbonic anhydrase 1, ... | 著者 | Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-10-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7Q0E
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![BU of 7q0e by Molmil](/molmil-images/mine/7q0e) | Human Carbonic Anhydrase II in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate | 分子名称: | BICINE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-10-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7PUW
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![BU of 7puw by Molmil](/molmil-images/mine/7puw) | Crystal structure of carbonic anhydrase XII with methyl 2-chloro-4-[(2-phenylethyl)sulfanyl]-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, Carbonic anhydrase 12, ZINC ION, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-09-30 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7PUV
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![BU of 7puv by Molmil](/molmil-images/mine/7puv) | Crystal structure of carbonic anhydrase XII with methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, Carbonic anhydrase 12, DI(HYDROXYETHYL)ETHER, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-09-30 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7Q0C
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![BU of 7q0c by Molmil](/molmil-images/mine/7q0c) | Mimic carbonic anhydrase IX in complex with Methyl 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate | 分子名称: | ACETATE ION, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-10-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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8P6U
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![BU of 8p6u by Molmil](/molmil-images/mine/8p6u) | Human carbonic anhydrase II containing 5-fluorotryptophanes | 分子名称: | BENZOIC ACID, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... | 著者 | Pham, L.B.T, Costantino, A, Barbieri, L, Calderone, V, Luchinat, E, Banci, L. | 登録日 | 2023-05-30 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Controlling the incorporation of fluorinated amino acids in human cells and its structural impact. Protein Sci., 33, 2024
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7PLF
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![BU of 7plf by Molmil](/molmil-images/mine/7plf) | Human Carbonic Anhydrase I in complex with clorsulon | 分子名称: | 4-azanyl-6-[1,2,2-tris(chloranyl)ethenyl]benzene-1,3-disulfonamide, Carbonic anhydrase 1, ZINC ION | 著者 | Angeli, A, Ferraroni, M. | 登録日 | 2021-08-31 | 公開日 | 2022-09-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.461 Å) | 主引用文献 | Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies. Acta Crystallogr D Struct Biol, 78, 2022
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8OKQ
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![BU of 8okq by Molmil](/molmil-images/mine/8okq) | Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI_2 | 分子名称: | Carbonic anhydrase 2, ZINC ION, [(3~{S},8~{R},9~{S},10~{R},13~{S},14~{S})-10,13-dimethyl-17-oxidanylidene-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] sulfamate | 著者 | Brynda, J, Rezacova, P.M, Kudova, E. | 登録日 | 2023-03-29 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Carbonic Anhydrase in Complex with Steriod_Sulphamoyl To Be Published
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8OLI
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![BU of 8oli by Molmil](/molmil-images/mine/8oli) | Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI_12 | 分子名称: | Carbonic anhydrase 2, ZINC ION, [(3~{R},5~{S},8~{R},9~{S},10~{S},13~{S},14~{S},17~{S})-17-ethanoyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl] sulfamate | 著者 | Brynda, J, Rezacova, P.M, Kudova, E. | 登録日 | 2023-03-30 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Carbonic Anhydrase in Complex with Steriod_Sulphamoyl To Be Published
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8OKP
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![BU of 8okp by Molmil](/molmil-images/mine/8okp) | Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor AKI_33 | 分子名称: | Carbonic anhydrase 2, ZINC ION, [(3~{R},5~{R},8~{R},9~{S},10~{S},13~{S},14~{S},15~{R})-10,13,15-trimethyl-17-oxidanylidene-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl] sulfamate | 著者 | Brynda, J, Rezacova, P.M, Kudova, E. | 登録日 | 2023-03-28 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Carbonic Anhydrase II in Complex with Steriod_Sulphamoyl To Be Published
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8OLK
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