2GD8

Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate

Summary for 2GD8

Entry DOI	10.2210/pdb2gd8/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	protein-inhibitor complexes, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30501.56
Authors	De Simone, G.,Di Fiore, A. (deposition date: 2006-03-15, release date: 2007-02-06, Last modification date: 2023-08-30)
Primary citation	Leese, M.P.,Leblond, B.,Smith, A.,Newman, S.P.,Di Fiore, A.,De Simone, G.,Supuran, C.T.,Purohit, A.,Reed, M.J.,Potter, B.V. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J.Med.Chem., 49:7683-7696, 2006 Cited by PubMed: 17181151 DOI: 10.1021/jm060705x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation