PDB: 47120 件ウェブページステータス検索Chemie searchBIRD

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6G8F	Crystal structure of UTX complexed with GSK-J1 分子名称: 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Esposito, C, Sledz, P, Caflisch, A. 登録日 2018-04-08 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.043 Å) 主引用文献 In Silico Identification of JMJD3 Demethylase Inhibitors. J Chem Inf Model, 58, 2018
4MY9	Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor C91 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase, MALONATE ION, ... 著者 Kim, Y, Makowska-Grzyska, M, Gu, M, Gorla, S.K, Hedstrom, L, Anderson, W.F, Joachimiak, A, CSGID, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2013-09-27 公開日 2014-06-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5893 Å) 主引用文献 Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor C91 To be Published
6G8Z	Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution 分子名称: Volume-regulated anion channel subunit LRRC8A 著者 Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R. 登録日 2018-04-10 公開日 2018-05-16 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.66 Å) 主引用文献 Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
8EYC	Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide 分子名称: Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1 著者 Morris, R, Kershaw, N.J, Babon, J.J. 登録日 2022-10-26 公開日 2023-08-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6, 2023
4N78	The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton 分子名称: Abl interactor 2, CHLORIDE ION, Cytoplasmic FMR1-interacting protein 1, ... 著者 Chen, Z.C. 登録日 2013-10-15 公開日 2014-02-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton. Cell(Cambridge,Mass.), 156, 2014
6G9U	Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide 分子名称: 4-[2-[3-(cyclooctylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid, Carbonic anhydrase 9, ZINC ION 著者 Leitans, J, Tars, K. 登録日 2018-04-11 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9, 2018
8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain 分子名称: Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-10-20 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8EZL	Pfs25 in complex with transmission-reducing antibody AS01-50 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... 著者 Shukla, N, Tang, W.K, Tolia, N.H. 登録日 2022-11-01 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A human antibody epitope map of the malaria vaccine antigen Pfs25. Npj Vaccines, 8, 2023
8F7K	Thermoplasma acidophilum 20S proteasome - wild type bound to ZYA 分子名称: N-[(benzyloxy)carbonyl]-L-tyrosyl-D-alanine, Proteasome subunit alpha, Proteasome subunit beta 著者 Chuah, J, Smith, D. 登録日 2022-11-18 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (1.94 Å) 主引用文献 High resolution structures define divergent and convergent mechanisms of archaeal proteasome activation. Commun Biol, 6, 2023
6FTE	Crystal structure of an (R)-selective amine transaminase from Exophiala xenobiotica 分子名称: ACETATE ION, Amine transaminase (fold IV), GLYCEROL, ... 著者 Telzerow, A, Hakansson, M, Schurrmann, M, Schwab, H, Steiner, K. 登録日 2018-02-21 公開日 2019-01-09 最終更新日 2020-01-29 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Amine Transaminase from Exophiala xenobiotica - Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones Acs Catalysis, 2018
8U8O	Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer-centered 分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, ... 著者 Calise, S.J, Kollman, J.M. 登録日 2023-09-18 公開日 2024-01-31 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
4KQA	Crystal structure of the golgi casein kinase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, Protein H03A11.1, ... 著者 Xiao, J. 登録日 2013-05-14 公開日 2013-06-26 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Crystal structure of the Golgi casein kinase. Proc.Natl.Acad.Sci.USA, 110, 2013
4KRA	Salmonella typhi OmpF complex with Ciprofloxacin 分子名称: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Outer membrane protein F 著者 Madhuranayaki, T, Balasubramaniam, D, Krishnaswamy, S. 登録日 2013-05-16 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Salmonella typhi OmpF complex with Ciprofloxacin To be published
8F66	Thermoplasma acidophilum 20S proteasome - L81Y mutation in alpha subunit 分子名称: Proteasome subunit alpha, Proteasome subunit beta 著者 Chuah, J, Smith, D. 登録日 2022-11-16 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (2.28 Å) 主引用文献 High resolution structures define divergent and convergent mechanisms of archaeal proteasome activation. Commun Biol, 6, 2023
6GCD	DNA binding domain of restriction endonuclease McrBC in complex with 5-hydroxymethylcytosine DNA 分子名称: 5-methylcytosine-specific restriction enzyme B, DNA (5'-D(*GP*AP*GP*AP*(5HC)P*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*(5HC)P*CP*GP*GP*TP*CP*TP*C)-3') 著者 Sasnauskas, G, Manakova, E. 登録日 2018-04-17 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of modified cytosine variants by the DNA-binding domain of methyl-directed endonuclease McrBC. FEBS Lett., 592, 2018
8U8Y	Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Calise, S.J, Kollman, J.M. 登録日 2023-09-18 公開日 2024-01-31 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly. J.Cell Biol., 223, 2024
7P37	Streptomyces coelicolor ATP-loaded NrdR 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ZINC ION 著者 Martinez-Carranza, M, Stenmark, P. 登録日 2021-07-07 公開日 2022-05-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022
6FV2	Structure of human coronavirus NL63 main protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl) 分子名称: (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide, 3C-like proteinase, GLYCEROL 著者 Zhang, L, Hilgenfeld, R. 登録日 2018-02-28 公開日 2019-03-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment. J.Med.Chem., 2020
8UM6	Structure of copper bound to YcnI W137F 分子名称: COPPER (II) ION, Uncharacterized protein YcnI 著者 Fisher, O.S, Silva, Y.R.O, Zheng, D. 登録日 2023-10-17 公開日 2024-02-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Stabilization of a Cu-binding site by a highly conserved tryptophan residue. J.Inorg.Biochem., 253, 2024
4KSL	Gumby/Fam105B in complex with linear di-ubiquitin 分子名称: Polyubiquitin-C, Protein FAM105B 著者 Juang, Y.-C, Ceccarelli, D.F, Sicheri, F. 登録日 2013-05-17 公開日 2013-06-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature, 498, 2013
7P4G	Rabbit Muscle L-lactate dehydrogenase in complex with citrate 分子名称: CITRIC ACID, L-lactate dehydrogenase A chain 著者 Iacovino, L.G, Binda, C, Hochkoeppler, A. 登録日 2021-07-11 公開日 2022-05-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme. Biochimie, 199, 2022
8FTE	CryoEM strucutre of 22-mer RBM2 of the Salmonella MS-ring 分子名称: Flagellar M-ring protein 著者 Singh, P.S, Nakagawa, T, Cecchini, G, Iverson, T.M. 登録日 2023-01-12 公開日 2023-05-31 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 CryoEM structure of a post-assembly MS-ring reveals plasticity in stoichiometry and conformation. Plos One, 18, 2023
7P0O	mitoNEET bound to M1 molecule 分子名称: 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, 2-benzamido-4-[(2~{S})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 1, ... 著者 Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. 登録日 2021-06-30 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters. Commun Biol, 5, 2022
4K4G	Ternary crystal structures of human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND L-DCTP. 分子名称: 4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one, ACETATE ION, CACODYLATE ION, ... 著者 Vyas, R, Suo, Z. 登録日 2013-04-12 公開日 2014-07-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda. Proc.Natl.Acad.Sci.USA, 111, 2014
7P3Q	Streptomyces coelicolor dATP/ATP-loaded NrdR octamer 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ... 著者 Martinez-Carranza, M, Stenmark, P. 登録日 2021-07-08 公開日 2022-05-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. Nat Commun, 13, 2022

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