6G9U
Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
Summary for 6G9U
| Entry DOI | 10.2210/pdb6g9u/pdb |
| Descriptor | Carbonic anhydrase 9, ZINC ION, 4-[2-[3-(cyclooctylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid, ... (4 entities in total) |
| Functional Keywords | lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 115018.76 |
| Authors | Leitans, J.,Tars, K. (deposition date: 2018-04-11, release date: 2018-07-04, Last modification date: 2024-01-17) |
| Primary citation | Kazokaite, J.,Niemans, R.,Dudutiene, V.,Becker, H.M.,Leitans, J.,Zubriene, A.,Baranauskiene, L.,Gondi, G.,Zeidler, R.,Matuliene, J.,Tars, K.,Yaromina, A.,Lambin, P.,Dubois, L.J.,Matulis, D. Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9:26800-26816, 2018 Cited by PubMed: 29928486DOI: 10.18632/oncotarget.25508 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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