PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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7CDE	Crystal structure of LSD1-CoREST in complex with PRSFLVRKR peptide 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... 著者 Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. 登録日 2020-06-19 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. J.Med.Chem., 64, 2021
7CDG	Crystal structure of LSD1-CoREST in complex with PRSFLVRRR peptide 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... 著者 Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. 登録日 2020-06-19 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. J.Med.Chem., 64, 2021
6ZWK	Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) 分子名称: CHLORIDE ION, Histone H2AX, SODIUM ION, ... 著者 McEwen, A.G, Moeglin, E, Desplancq, D, Weiss, E, Poterszman, A. 登録日 2020-07-28 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress. Cancers (Basel), 13, 2021
4Q0N	Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand 分子名称: (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Monteiro, O, Fedorov, O, Chaikuad, A, Yue, W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2014-04-02 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand To be Published
6ZUE	Crystal structure of human DDB1 bound to human DCAF1 (amino acid residues 1046-1396) 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Schwefel, D, Taylor, I.A. 登録日 2020-07-22 公開日 2021-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.094 Å) 主引用文献 Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. Plos Pathog., 17, 2021
2JRS	Solution NMR Structure of CAPER RRM2 Domain. Northeast Structural Genomics Target HR4730A 分子名称: RNA-binding protein 39 著者 Rossi, P, Zhao, L, Nwosu, C, Cunningham, K, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2007-06-28 公開日 2007-09-04 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of CAPER RRM2 Domain. To be Published
4Q6F	Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3K4 histone peptide 分子名称: 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2A, ZINC ION, ... 著者 Tallant, C, Overvoorde, L, Krojer, T, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Ciulli, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2014-04-22 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
7CUX	Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding 分子名称: Schlafen family member 5, ZINC ION 著者 Yang, J.Y, Luo, M, Ou, J.Y, Wang, Z.W, Gao, S. 登録日 2020-08-25 公開日 2021-08-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.29477072 Å) 主引用文献 Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding To Be Published
2JY8	NMR structure of the ubiquitin associated (UBA) domain of p62 (SQSTM1) in complex with ubiquitin. RDC refined 分子名称: Ubiquitin-binding protein p62 著者 Long, J.E, Layfield, R, Searle, M.S. 登録日 2007-12-07 公開日 2007-12-18 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ubiquitin Recognition by the Ubiquitin-associated Domain of p62 Involves a Novel Conformational Switch J.Biol.Chem., 283, 2008
7DHG	Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 分子名称: Mitochondrial import receptor subunit TOM70, ORF9b protein 著者 Gao, X, Zhu, K, Qin, B, Olieric, V, Wang, M, Cui, S. 登録日 2020-11-14 公開日 2021-05-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun, 12, 2021
2JVN	Domain C of human PARP-1 分子名称: Poly [ADP-ribose] polymerase 1, ZINC ION 著者 Hoffman, D, Tao, Z, Liu, H. 登録日 2007-09-24 公開日 2008-05-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry, 47, 2008
2J4Z	Structure of Aurora-2 in complex with PHA-680626 分子名称: 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC, SERINE THREONINE-PROTEIN KINASE 6 著者 Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P. 登録日 2006-09-08 公開日 2006-11-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. J. Med. Chem., 49, 2006
7DCJ	Crystal structure of HSF1 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation 分子名称: DNA (5'-D(*GP*CP*CP*GP*AP*AP*TP*AP*TP*TP*CP*GP*G)-3'), Heat shock factor protein 1, SODIUM ION 著者 Feng, N, Liu, W. 登録日 2020-10-26 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
7DCT	Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (24 bp) 分子名称: DNA (5'-D(*AP*CP*TP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*AP*G)-3'), Heat shock factor protein 1, ... 著者 Feng, N, Liu, W. 登録日 2020-10-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
7DCU	Crystal structure of HSF2 DNA-binding domain in complex with 3-site HSE DNA (21 bp) 分子名称: DNA (5'-D(*AP*CP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*G)-3'), Heat shock factor protein 2, ... 著者 Feng, N, Liu, W. 登録日 2020-10-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
7DCS	Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (23 bp) 分子名称: DNA (5'-D(*AP*TP*CP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*GP*A)-3'), Heat shock factor protein 1, ... 著者 Feng, N, Liu, W. 登録日 2020-10-27 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
7DCI	Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation 分子名称: DNA (5'-D(*GP*GP*GP*AP*AP*TP*AP*TP*TP*CP*CP*C)-3'), Heat shock factor protein 2, SODIUM ION 著者 Wei, L, Wei, L. 登録日 2020-10-26 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation To Be Published
7AUD	Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ... 著者 Chen, X, Oliver, A.W. 登録日 2020-11-02 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
4QB3	Crystal structure of the first bromodomain of human BRD4 in complex with Olinone 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide 著者 Plotnikov, A.N, Joshua, J, Zhou, M.-M. 登録日 2014-05-06 公開日 2015-04-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (0.94 Å) 主引用文献 Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem.Biol., 21, 2014
7B2X	Crystal structure of human 5' exonuclease Appollo H61Y variant 分子名称: 5' exonuclease Apollo, NICKEL (II) ION 著者 Newman, J.A, Baddock, H.T, Mukhopadhyay, S.M.M, Burgess-Brown, N.A, von Delft, F, Arrowshmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2020-11-28 公開日 2021-01-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Nucleic Acids Res., 49, 2021
7AYI	Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2a) 分子名称: 7-(2-phenylazanylpyrimidin-4-yl)-1,3,4,5-tetrahydro-1-benzazepin-2-one, Aurora kinase A 著者 Chaikuad, A, Karatas, M, Kunick, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-11-12 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules, 26, 2021
4QF2	Crystal structure of human BAZ2A PHD zinc finger in the free form 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, GLYCEROL, PHOSPHATE ION, ... 著者 Tallant, C, Overvoorde, L, Van Molle, I, Chirgadze, D.Y, Ciulli, A. 登録日 2014-05-19 公開日 2014-07-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
7AUC	Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Chen, X, Oliver, A.W. 登録日 2020-11-02 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
2IE7	Annexin V under 2.0 MPa pressure of nitrous oxide 分子名称: Annexin A5, CALCIUM ION, NITROUS OXIDE, ... 著者 Colloc'h, N, Sopkova-de Oliveira Santos, J, Prange, T, Brisson, A, Langlois d'Estainto, B, Gallois, B. 登録日 2006-09-18 公開日 2007-02-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action Biophys.J., 92, 2007
2IG0	Structure of 53BP1/methylated histone peptide complex 分子名称: Dimethylated Histone H4-K20 peptide, SULFATE ION, Tumor suppressor p53-binding protein 1 著者 Mer, G. 登録日 2006-09-22 公開日 2007-01-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell(Cambridge,Mass.), 127, 2006

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