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7CDG

Crystal structure of LSD1-CoREST in complex with PRSFLVRRR peptide

Summary for 7CDG
Entry DOI10.2210/pdb7cdg/pdb
DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, PRO-ARG-SER-PHE-LEU-VAL-ARG-ARG-ARG, ... (6 entities in total)
Functional Keywordsdemethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight92528.34
Authors
Kikuchi, M.,Kitagawa, H.,Sato, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2020-06-19, release date: 2021-06-23, Last modification date: 2023-11-29)
Primary citationKitagawa, H.,Kikuchi, M.,Sato, S.,Watanabe, H.,Umezawa, N.,Kato, M.,Hisamatsu, Y.,Umehara, T.,Higuchi, T.
Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64:3707-3719, 2021
Cited by
PubMed: 33754721
DOI: 10.1021/acs.jmedchem.0c01371
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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