PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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6NFF	Structure of X-prolyl dipeptidyl aminopeptidase from Lactobacillus helveticus 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, PHOSPHATE ION, ... 著者 Juers, D.H, Bratt, N.J, Ojennus, D.D. 登録日 2018-12-20 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural characterization of a prolyl aminodipeptidase (PepX) from Lactobacillus helveticus. Acta Crystallogr.,Sect.F, 75, 2019
6NNY	Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39E:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.67 Angstrom Resolution 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Ghanbarpour, A, Geiger, J. 登録日 2019-01-15 公開日 2019-01-30 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.668 Å) 主引用文献 Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39E:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.68 Angstrom Resolution To Be Published
6QC0	PCNA complex with Cdt2 C-terminal PIP-box peptide 分子名称: Denticleless protein homolog, Proliferating cell nuclear antigen 著者 Perrakis, A.P, von Castelmur, E. 登録日 2018-12-25 公開日 2019-01-23 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1. Life Sci Alliance, 1, 2018
6QCG	PCNA complex with Cdt1 N-terminal PIP-box peptide 分子名称: DNA replication factor Cdt1, Proliferating cell nuclear antigen 著者 Perrakis, A, von Castelmur, E. 登録日 2018-12-28 公開日 2019-01-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1. Life Sci Alliance, 1, 2018
8VVJ	Structure of S. odontolytica ZTP riboswitch bound to m-1-pyridinyl-AICA 分子名称: (1M)-5-amino-1-(1,8-naphthyridin-3-yl)-1H-imidazole-4-carboxamide, MAGNESIUM ION, RNA (64-MER) 著者 Jones, C.P, Ferre D'Amare, A.R. 登録日 2024-01-31 公開日 2025-06-11 最終更新日 2025-08-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands. Angew.Chem.Int.Ed.Engl., 64, 2025
8SZ2	Stx2A1 bound to P8 stalk peptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ... 著者 rudolph, M.J, Li, X.P. 登録日 2023-05-26 公開日 2024-05-29 最終更新日 2024-12-11 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure-Function Analysis of the A1 Subunit of Shiga Toxin 2 with Peptides That Target the P-Stalk Binding Site and Inhibit Activity. Biochemistry, 63, 2024
6NYO	Crystal structure of a human Cdc34-ubiquitin thioester mimetic 分子名称: 1,2-ETHANEDIOL, 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, PHOSPHATE ION, ... 著者 Olsen, S.K, Williams, K.M, Atkison, J.H. 登録日 2019-02-11 公開日 2019-08-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34. Nat Commun, 10, 2019
8RCZ	Structure of the enoyl-ACP reductase FabV from Pseudomonas aeruginosa with NADH cofactor 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH] 著者 Vandebroek, L, Van Olmen, F, Voet, A.R.D, Verwilst, P. 登録日 2023-12-07 公開日 2024-12-18 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure of the enoyl-ACP reductase FabV from Pseudomonas aeruginosa with NADH cofactor To Be Published
6O8C	Crystal structure of STING CTT in complex with TBK1 分子名称: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein 著者 Li, P, Zhao, B, Du, F. 登録日 2019-03-09 公開日 2019-05-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
6O8B	Crystal structure of STING CTD in complex with TBK1 分子名称: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein 著者 Li, P, Zhao, B, Du, F. 登録日 2019-03-09 公開日 2019-05-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
6OCA	Ricin A chain bound to VHH antibody V2G10 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... 著者 Rudolph, M.J. 登録日 2019-03-22 公開日 2020-04-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.113 Å) 主引用文献 Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
6OD4	Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*CP*GP*TP*GP*TP*A)-3'), Transcription factor 4 著者 Horton, J.R, Cheng, X, Yang, J. 登録日 2019-03-25 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
6QNI	Liquid Application Method for time-resolved Analyses (LAMA) by serial synchrotron crystallography, Xylose Isomerase 1.0 s timepoint 分子名称: COBALT (II) ION, MAGNESIUM ION, Xylose isomerase, ... 著者 Mehrabi, P, Schulz, E.C, Miller, R.J.D. 登録日 2019-02-11 公開日 2019-10-02 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.846 Å) 主引用文献 Liquid application method for time-resolved analyses by serial synchrotron crystallography. Nat.Methods, 16, 2019
6OJD	A high-resolution crystal structure of covalent complex of NocB thioesterase domain with fluorophosphonate nocardicin G analog 分子名称: (R)-[(S)-[(3S)-3-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoazetidin-1-yl](4-hydroxyphenyl)methyl]methylphosphinic acid, CALCIUM ION, GLYCEROL, ... 著者 Patel, K.D, Gulick, A.M. 登録日 2019-04-11 公開日 2019-09-11 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions. Nat Commun, 10, 2019
6QV7	Crystal structure of a CHAD domain from Chlorobium tepidum 分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, SULFATE ION, ... 著者 Lorenzo-Orts, L, Hothorn, M. 登録日 2019-03-01 公開日 2019-05-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules. Life Sci Alliance, 2, 2019
6O39	Crystal structure of Frizzled 5 CRD in complex with F2.I Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. 登録日 2019-02-26 公開日 2019-04-03 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
7RTE	X-ray structure of wild type RBPJ-L3MBTL3-DNA complex 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ... 著者 Hall, D.P, Kovall, R.A, Yuan, Z. 登録日 2021-08-13 公開日 2022-08-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3. Nucleic Acids Res., 50, 2022
7PCM	BurG (holo) in complex with (Z)-2,3-dihydroxy-6-methyl-hept-2-enoate (13): Biosynthesis of cyclopropanol rings in bacterial toxins 分子名称: (Z)-6-methyl-2,3-bis(oxidanyl)hept-2-enoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, ... 著者 Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. 登録日 2021-08-03 公開日 2022-08-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat.Chem., 14, 2022
6WIT	Crystal structure of NHP D15.SD7 Fab in complex with 16055 V1V2 1FD6 scaffold 分子名称: 16055 V1V2 1FD6 Scaffold, 2-acetamido-2-deoxy-beta-D-glucopyranose, NHP GN1-SD7 Fab Heavy Chain, ... 著者 Liban, T, Aljedani, S, Rodarte, J, Pancera, M. 登録日 2020-04-10 公開日 2021-04-14 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization. Plos Pathog., 17, 2021
6RB4	Crystal structure of the Pri1 subunit of human primase 分子名称: 1,2-ETHANEDIOL, DNA primase small subunit, ZINC ION 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2019-04-09 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol., 14, 2019
6OB6	Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned 分子名称: 6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine, Equilibrative nucleoside transporter 1 著者 Wright, N.J, Lee, S.-Y. 登録日 2019-03-19 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of human ENT1 in complex with adenosine reuptake inhibitors. Nat.Struct.Mol.Biol., 26, 2019
6OBE	Ricin A chain bound to VHH antibody V6H8 分子名称: 1,2-ETHANEDIOL, IMIDAZOLE, NICKEL (II) ION, ... 著者 Rudolph, M.J. 登録日 2019-03-20 公開日 2020-04-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.732 Å) 主引用文献 Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
6OBO	Ricin A chain bound to VHH antibody V6A6 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... 著者 Rudolph, M.J. 登録日 2019-03-21 公開日 2020-04-01 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
7Q7Y	Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative) 分子名称: GUANINE, MAGNESIUM ION, RNA 1, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
8SPE	Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ... 著者 Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E. 登録日 2023-05-03 公開日 2023-12-27 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024

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