6WIT

Crystal structure of NHP D15.SD7 Fab in complex with 16055 V1V2 1FD6 scaffold

Summary for 6WIT

• Entry DOI: 10.2210/pdb6wit/pdb
• Related: 6VJN 6WAS
• Descriptor: NHP GN1-SD7 Fab Heavy Chain, NHP GN1-SD7 Fab Light Chain, 16055 V1V2 1FD6 Scaffold, ... (6 entities in total)
• Functional Keywords: fab, hiv, v1v2, complex, antibody, scaffold, antiviral protein-immune system complex, antiviral protein/immune system
• Biological source: Macaca mulatta (Rhesus monkey); More
• Total number of polymer chains: 6
• Total formula weight: 125063.11

Authors

Liban, T.,Aljedani, S.,Rodarte, J.,Pancera, M. (deposition date: 2020-04-10, release date: 2021-04-14, Last modification date: 2023-10-18)

• Primary citation: Aljedani, S.S.,Liban, T.J.,Tran, K.,Phad, G.,Singh, S.,Dubrovskaya, V.,Pushparaj, P.,Martinez-Murillo, P.,Rodarte, J.,Mileant, A.,Mangala Prasad, V.,Kinzelman, R.,O'Dell, S.,Mascola, J.R.,Lee, K.K.,Karlsson Hedestam, G.B.,Wyatt, R.T.,Pancera, M.; Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.; Plos Pathog., 17:e1009543-e1009543, 2021; PubMed: 34559844; DOI: 10.1371/journal.ppat.1009543

Experimental method

X-RAY DIFFRACTION (2.79 Å)