PDB: 5434 件ウェブページステータス検索Chemie searchBIRD

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2IG0	Structure of 53BP1/methylated histone peptide complex 分子名称: Dimethylated Histone H4-K20 peptide, SULFATE ION, Tumor suppressor p53-binding protein 1 著者 Mer, G. 登録日 2006-09-22 公開日 2007-01-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell(Cambridge,Mass.), 127, 2006
7QDL	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 with I-BET567 分子名称: (2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Chung, C. 登録日 2021-11-27 公開日 2022-12-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. J.Med.Chem., 65, 2022
8K4L	Crystal structure of NRF1 homodimer in complex with DNA 分子名称: DNA (14-MER), GLYCEROL, Nuclear respiratory factor 1 著者 Liu, K, Li, W.F, Min, J.R. 登録日 2023-07-19 公開日 2023-12-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular mechanism of specific DNA sequence recognition by NRF1. Nucleic Acids Res., 52, 2024
2JVN	Domain C of human PARP-1 分子名称: Poly [ADP-ribose] polymerase 1, ZINC ION 著者 Hoffman, D, Tao, Z, Liu, H. 登録日 2007-09-24 公開日 2008-05-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry, 47, 2008
7QNZ	human Lig1-DNA-PCNA complex reconstituted in absence of ATP 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.58 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
2JHW	CRYSTAL STRUCTURE OF RHOGDI E155A, E157A MUTANT 分子名称: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION 著者 Cooper, D.R, Grelewska, K, Derewenda, Z.S. 登録日 2007-02-23 公開日 2007-05-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Protein Crystallization by Surface Entropy Reduction: Optimization of the Ser Strategy Acta Crystallogr.,Sect.D, 63, 2007
8OOI	Full composite cryo-EM map of p97/VCP in ADP.Pi state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cheng, T.C, Sakata, E, Schuetz, A.K. 登録日 2023-04-05 公開日 2024-01-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Characterizing ATP processing by the AAA+ protein p97 at the atomic level. Nat.Chem., 16, 2024
7AUC	Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Chen, X, Oliver, A.W. 登録日 2020-11-02 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10, 2021
2JHU	CRYSTAL STRUCTURE OF RHOGDI E154A,E155A MUTANT 分子名称: RHO GDP-DISSOCIATION INHIBITOR 1, SULFATE ION 著者 Cooper, D.R, Pinkowska, M, Derewenda, Z.S. 登録日 2007-02-23 公開日 2007-05-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Protein Crystallization by Surface Entropy Reduction: Optimization of the Ser Strategy Acta Crystallogr.,Sect.D, 63, 2007
7QXX	Proteasome-ZFAND5 Complex Z+E state 分子名称: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-27 公開日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXN	Proteasome-ZFAND5 Complex Z+A state 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-26 公開日 2023-02-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXP	Proteasome-ZFAND5 Complex Z+B state 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-26 公開日 2023-02-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QYB	Proteasome-ZFAND5 Complex Z-C state 分子名称: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-27 公開日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXU	Proteasome-ZFAND5 Complex Z+C state 分子名称: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-27 公開日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7QXW	Proteasome-ZFAND5 Complex Z+D state 分子名称: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-27 公開日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
7AYH	Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2c) 分子名称: 7-[2-[(4-methoxyphenyl)amino]pyrimidin-4-yl]-1,3,4,5-tetrahydro-1-benzazepin-2-one, Aurora kinase A 著者 Chaikuad, A, Karatas, M, Kunick, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-11-12 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules, 26, 2021
8OK2	Bipartite interaction of TOPBP1 with the GINS complex 分子名称: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ... 著者 Day, M, Oliver, A.W, Pearl, L.H. 登録日 2023-03-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nat Commun, 15, 2024
7AXS	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1 分子名称: CS-VIP8, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... 著者 Cretu, C, Pena, V. 登録日 2022-01-15 公開日 2023-05-10 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of catalytic activation in human splicing. Nature, 617, 2023
8ODP	Structure of human RTCB with GMPCPP in complex with Archease 分子名称: MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Protein archease, ... 著者 Kopp, J, Gerber, J.L, Peschek, J. 登録日 2023-03-09 公開日 2024-03-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. Nat Commun, 15, 2024
7REL	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-060 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-methylpyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-07-13 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-060 To Be Published
7REM	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050 分子名称: Bromodomain-containing protein 4, N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-07-13 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050 To Be Published
8OF5	Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Miles, J.A, Hammond, K.L.R, Bayliss, R. 登録日 2023-03-14 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP To Be Published
7REK	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-07-13 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086 To Be Published
8K14	X-ray crystal structure of 18a in BRD4(1) 分子名称: 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4 著者 Xu, H, Shen, H, Zhang, Y, Xu, Y, Li, R. 登録日 2023-07-10 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation. Eur.J.Med.Chem., 263, 2024

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