PDB: 19040 件ウェブページステータス検索Chemie searchBIRD

---

7WAY	PlmCasX-sgRNAv1-dsDNA ternary complex at nts loading state 分子名称: DNA (27-MER), DNA (33-MER), RNA, ... 著者 Zhang, S, Liu, J.J.G. 登録日 2021-12-15 公開日 2022-03-16 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. Mol.Cell, 82, 2022
7WB1	PlmCasX-sgRNAv2-dsDNA ternary complex at nts loading state 分子名称: NTS-DNA, RNA (121-MER), TS-DNA, ... 著者 Zhang, S, Liu, J.J.G. 登録日 2021-12-15 公開日 2022-03-16 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. Mol.Cell, 82, 2022
3KMN	Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant 分子名称: CALCIUM ION, CARBONATE ION, Glutathione S-transferase P, ... 著者 Parker, L.J. 登録日 2009-11-11 公開日 2010-03-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V to be published
1MHD	CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA 分子名称: DNA, SMAD3 著者 Shi, Y. 登録日 1998-08-18 公開日 1999-08-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell(Cambridge,Mass.), 94, 1998
6QG4	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine inhibitor 1h 分子名称: 1-[(3~{R})-3-[4-azanyl-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QFT	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b 分子名称: 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QFL	Structure of the mitogen activated kinase kinase 7 active conformation 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QG7	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k 分子名称: (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2019-06-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QHR	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1m 分子名称: 1-[(3~{R})-3-[4-azanyl-3-(1~{H}-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-17 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QHO	Dual specificity mitogen-activated protein kinase kinase 7 in complex with pyrazolopyrimidine 1a 分子名称: 1-[(3~{R})-3-(4-azanylpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-17 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QFR	Structure of the mitogen activated kinase kinase 7 dfg-out conformation 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6R7I	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. 登録日 2019-03-28 公開日 2019-08-28 最終更新日 2019-09-04 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
6R6H	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Morris, E.P, Faull, S.V, Lau, A.M.C, Politis, A, Beuron, F, Cronin, N. 登録日 2019-03-27 公開日 2019-08-28 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (8.4 Å) 主引用文献 Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
6R7H	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Faull, S.V, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. 登録日 2019-03-28 公開日 2019-08-28 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (8.8 Å) 主引用文献 Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
1MD4	A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase 著者 Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W. 登録日 2002-08-06 公開日 2002-08-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1 J.Biol.Chem., 278, 2003
6R7F	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Faull, S.V, Lau, A.M.C, Martens, C, Ahdash, Z, Yebenes, H, Schmidt, C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. 登録日 2019-03-28 公開日 2019-08-28 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (8.2 Å) 主引用文献 Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
1MD3	A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase 著者 Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W. 登録日 2002-08-06 公開日 2002-08-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1 J.Biol.Chem., 278, 2003
3KM6	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate 分子名称: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ... 著者 Parker, L.J. 登録日 2009-11-10 公開日 2010-03-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J.Mol.Recognit., 24
1LBK	Crystal structure of a recombinant glutathione transferase, created by replacing the last seven residues of each subunit of the human class pi isoenzyme with the additional C-terminal helix of human class alpha isoenzyme 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, Glutathione S-transferase class pi chimaera (CODA), ... 著者 Kong, G.K.W, Micaloni, C, Mazzetti, A.P, Nuccetelli, M, Antonini, G, Stella, L, McKinstry, W.J, Polekhina, G, Rossjohn, J, Federici, G, Ricci, G, Parker, M.W, Lo Bello, M. 登録日 2002-04-04 公開日 2002-04-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. J.Mol.Biol., 325, 2003
3KMO	Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT) 分子名称: CALCIUM ION, ETHACRYNIC ACID, GLUTATHIONE, ... 著者 Parker, L.J. 登録日 2009-11-11 公開日 2010-03-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V To be Published
8AFK	Structure of iRFP variant C15S/N136R/V256C in complex with phycocyanobilin 分子名称: Near-infrared fluorescent protein, PHYCOCYANOBILIN 著者 Remeeva, A, Kovalev, K, Gushchin, I, Fonin, A, Turoverov, K, Stepanenko, O. 登録日 2022-07-18 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.015 Å) 主引用文献 Structure of iRFP variant C15S/N136R/V256C in complex with phycocyanobilin To Be Published
8AM0	Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) 分子名称: (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Goncalves, M, Johnson, J.L, Roewer, K.M. 登録日 2022-08-02 公開日 2023-12-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.818 Å) 主引用文献 Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42, 2023
8C17	Crystal structure of TEAD4 in complex with peptide 1 分子名称: GLYCEROL, MYRISTIC ACID, Stapled peptide, ... 著者 Scheufler, C, Kallen, J. 登録日 2022-12-20 公開日 2023-03-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD. Acs Chem.Biol., 18, 2023
8CAA	Crystal structure of TEAD4 in complex with YTP-13 分子名称: (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, PHOSPHATE ION, ... 著者 Scheufler, C, Kallen, J. 登録日 2023-01-24 公開日 2023-04-12 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. Chemmedchem, 18, 2023
8CK3	STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-(3,5-Difluoro-phenyl)-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol 分子名称: (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, DIMETHYL SULFOXIDE, ... 著者 Musil, D, Lehmannn, M, Diehl, L. 登録日 2023-02-14 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.707 Å) 主引用文献 Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors. J.Med.Chem., 66, 2023

<137138139140141142143144145146147148149150151152>