3KMN

Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant

Summary for 3KMN

• Entry DOI: 10.2210/pdb3kmn/pdb
• Related: 3KM6 3KMO
• Descriptor: Glutathione S-transferase P, CALCIUM ION, CARBONATE ION, ... (5 entities in total)
• Functional Keywords: transferase, glutathione, detoxification, double mutant, ethacrynic acid, diuretic drug, dimer interface
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P09211
• Total number of polymer chains: 2
• Total formula weight: 46788.38

Authors

Parker, L.J. (deposition date: 2009-11-11, release date: 2010-03-23, Last modification date: 2021-11-10)

• Primary citation: Quesada-Soriano, I.,Parker, L.J.,Primavera, A.,Wielens, J.,Holien, J.K.,Casas-Solvas, J.M.,Vargas-Berenguel, A.,Aguilera, A.,Nuccetelli, N.,Mazzetti, A.P.,Lo Bello, M.,Parker, M.W.,Garcia-Fuentes, L.; Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V; to be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)