3KM6

Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate

Summary for 3KM6

Entry DOI	10.2210/pdb3km6/pdb
Related	3KMN 3KMO
Descriptor	Glutathione S-transferase P, ETHACRYNIC ACID, GLUTATHIONE, ... (5 entities in total)
Functional Keywords	transferase, glutathione, detoxification, double mutant, ethacrynic acid, diuretic drug, dimer interface
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	47794.32
Authors	Parker, L.J. (deposition date: 2009-11-10, release date: 2010-03-23, Last modification date: 2023-11-01)
Primary citation	Quesada-Soriano, I.,Parker, L.J.,Primavera, A.,Wielens, J.,Holien, J.K.,Casas-Solvas, J.M.,Vargas-Berenguel, A.,Aguilera, A.M.,Nuccetelli, M.,Mazzetti, A.P.,Lo Bello, M.,Parker, M.W.,Garcia-Fuentes, L. Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J.Mol.Recognit., 24:220-234, Cited by PubMed: 20540076 DOI: 10.1002/jmr.1040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation