3KM6
Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutathione S-transferase P | polymer | 209 | 23166.5 | 2 | UniProt (P09211) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (human) | GST class-pi, GSTP1-1 |
| 2 | C, H (A, B) | ETHACRYNIC ACID | non-polymer | 303.1 | 2 | Chemie (EAA) | |||
| 3 | D, G (A, B) | GLUTATHIONE | non-polymer | 307.3 | 2 | Chemie (GSH) | |||
| 4 | E, F, I, J, K... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 477 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 209 (UniProt: P09211)
| PDB | External Database | Details |
|---|---|---|
| Ser 47 | Cys 48 | engineered mutation |
| Val 108 | Tyr 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46332.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1461.4 | |
| All* | Total formula weight | 47794.3 |
