PDB: 47120 件ウェブページステータス検索Chemie searchBIRD

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8EF8	Staphylococcus aureus ClpP Y63W in complex with compound 3471 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, (5S,6S,9aS)-N-[(4-fluorophenyl)methyl]-6-methyl-8-[(naphthalen-1-yl)methyl]-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide, ATP-dependent Clp protease proteolytic subunit 著者 Lee, R.E, Griffith, E.C. 登録日 2022-09-08 公開日 2023-07-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Development of a high throughput and site specific, fluorescent polarization assay to screen for activators of Caseinolytic Protease P leads to the discovery of synthetically tractable new activator class To Be Published
8ETS	Class1 of the INO80-Hexasome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... 著者 Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. 登録日 2022-10-17 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
8STS	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a non-nucleoside inhibitor 分子名称: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... 著者 Hollander, K, Jorgensen, W.L, Anderson, K.S. 登録日 2023-05-11 公開日 2023-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
8STU	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-6-fluoroindolizine-2-carbonitrile (JLJ578), a non-nucleoside inhibitor 分子名称: 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... 著者 Hollander, K, Jorgensen, W.L, Anderson, K.S. 登録日 2023-05-11 公開日 2023-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
8ETU	Class2 of the INO80-Hexasome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... 著者 Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. 登録日 2022-10-17 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
8ETW	Class3 of INO80-Hexasome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... 著者 Wu, H, Munoz, E, Gourdet, M, Narlikar, G, Cheng, Y.F. 登録日 2022-10-17 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
4LUH	Complex of ovine serum albumin with 3,5-diiodosalicylic acid 分子名称: (2R)-2-{[(2R)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propyl]oxy}propan-1-ol, (2S)-2-hydroxybutanedioic acid, 2-HYDROXY-3,5-DIIODO-BENZOIC ACID, ... 著者 Bujacz, A, Talaj, J.A, Pietrzyk, A.J, Bujacz, G. 登録日 2013-07-25 公開日 2014-09-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of ovine serum albumin and its complex with 3,5-diiodosalicylic acid To be Published
8STV	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor 分子名称: 1,2-ETHANEDIOL, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, MAGNESIUM ION, ... 著者 Hollander, K, Jorgensen, W.L, Anderson, K.S. 登録日 2023-05-11 公開日 2023-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
8EOH	crystal structure of human Cytochrome P450 8B1 in complex with a C12-Pyridine Containing Steroid 分子名称: 12-(pyridin-3-yl)-8alpha,10alpha,13alpha,14beta-androsta-4,11-diene-3,17-dione, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Liu, J, Scott, E.E. 登録日 2022-10-03 公開日 2023-08-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281. J.Biol.Chem., 299, 2023
6EFX	Crystal structure of a YjeF family protein from Cryptococcus neoformans var. grubii serotype A in complex with AMPPNP 分子名称: 1,2-ETHANEDIOL, ATP-dependent (S)-NAD(P)H-hydrate dehydratase, MAGNESIUM ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-08-17 公開日 2018-09-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a YjeF family protein from Cryptococcus neoformans var. grubii serotype A in complex with AMPPNP TO BE PUBLISHED
6E8S	Structure of the iMango-III aptamer bound to TO1-Biotin 分子名称: 4-[(3-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-1,3-benzothiazol-3-ium-2-yl)methyl]-1-methylquinolin-1-ium, MAGNESIUM ION, POTASSIUM ION, ... 著者 Trachman, R.J, Ferre-D'Amare, A.R. 登録日 2018-07-31 公開日 2019-04-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nat. Chem. Biol., 15, 2019
6EGZ	Crystal structure of cytochrome c in complex with di-PEGylated sulfonatocalix[4]arene 分子名称: Cytochrome c iso-1, HEME C, SODIUM ION, ... 著者 Mummidivarapu, V.V.S, Rennie, M.L, Crowley, P.B. 登録日 2017-09-12 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Noncovalent PEGylation via Sulfonatocalix[4]arene-A Crystallographic Proof. Bioconjug.Chem., 29, 2018
8EIH	Cryo-EM structure of human DNMT3B homo-tetramer (form I) 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8SPE	Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31 分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ... 著者 Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E. 登録日 2023-05-03 公開日 2023-12-27 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. Febs J., 291, 2024
8EII	Cryo-EM structure of human DNMT3B homo-tetramer (form II) 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
6EHN	Structural insight into a promiscuous CE15 esterase from the marine bacterial metagenome 分子名称: Carbohydrate esterase MZ0003, GLYCEROL 著者 Helland, R, De Santi, C, Gani, O, Williamson, A.K. 登録日 2017-09-13 公開日 2018-03-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insight into a CE15 esterase from the marine bacterial metagenome. Sci Rep, 7, 2017
8SH2	KLHDC2 in complex with EloB and EloC 分子名称: Elongin-B, Elongin-C, Kelch domain-containing protein 2 著者 Digianantonio, K.M, Bekes, M. 登録日 2023-04-13 公開日 2024-01-03 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
6E9K	The crystal structure of bovine ultralong antibody BOV-5 分子名称: Bovine ultralong antibody BOV-5 heavy chain, IGL@ protein 著者 Dong, J, Crowe, J.E. 登録日 2018-08-01 公開日 2019-05-01 実験手法 X-RAY DIFFRACTION (2.193 Å) 主引用文献 Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains. Front Immunol, 10, 2019
8EIK	Cryo-EM structure of human DNMT3B homo-hexamer 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8ENR	Cryo-EM structure of E. coli CsgA fibril (260 pixel box size) 分子名称: Major curlin subunit 著者 Bu, F, Liu, B. 登録日 2022-09-30 公開日 2023-10-04 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural insight into Escherichia coli CsgA amyloid fibril assembly. Mbio, 15, 2024
7NL8	Crystal structure of a shortened IpgC variant in complex with 3-methylbenzohydrazide 分子名称: 3-methylbenzohydrazide, CHLORIDE ION, Chaperone protein IpgC, ... 著者 Gardonyi, M, Heine, A, Klebe, G. 登録日 2021-02-22 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Crystal structure of a shortened IpgC variant in complex with 3-methylbenzohydrazide To be published
6EJ5	A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner 分子名称: Regulator of nonsense transcripts 1 著者 Gowravaram, M, Bonneau, F, Maciej, V.D, Chakrabarti, S. 登録日 2017-09-20 公開日 2018-01-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner. Nucleic Acids Res., 46, 2018
8SXQ	Crystal structure of Sel-1 repeat protein LceB from Legionella pneumophila 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, SEL-1 repeat protein 著者 Penner, T.V, Prehna, G. 登録日 2023-05-23 公開日 2024-01-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural characterization of the Sel1-like repeat protein LceB from Legionella pneumophila. Protein Sci., 33, 2024
7NHW	Crystal structure of a shortened IpgC variant in complex with chlorzoxazone 分子名称: CHLORIDE ION, CHLORZOXAZONE, Chaperone protein IpgC, ... 著者 Gardonyi, M, Heine, A, Klebe, G. 登録日 2021-02-11 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal structure of a shortened IpgC variant in complex with chlorzoxazone To be published
8EKM	Clostridioides difficile binary toxin translocase CDTb double mutant - D623A D734A 分子名称: ADP-ribosyltransferase binding component, CALCIUM ION 著者 Abeyawardhane, D.L, Pozharski, E. 登録日 2022-09-21 公開日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.56 Å) 主引用文献 Calcium-mediated Pore Formation of Clostridioides difficile Binary Toxin To Be Published

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