PDB: 243911 件ウェブページステータス検索Chemie searchBIRD

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4NGA	Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide 分子名称: (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide, CALCIUM ION, Factor VIIa (Heavy Chain), ... 著者 Wei, A, Anumula, R. 登録日 2013-11-01 公開日 2014-01-08 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors. ACS Med Chem Lett, 5, 2014
5WN2	APE1 exonuclease substrate complex with phosphoglycolate 分子名称: 1,2-ETHANEDIOL, 2-PHOSPHOGLYCOLIC ACID, CALCIUM ION, ... 著者 Freudenthal, B.D, Whitaker, A.M. 登録日 2017-07-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.288 Å) 主引用文献 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun, 9, 2018
4NH2	Crystal structure of AmtB from E. coli bound to phosphatidylglycerol 分子名称: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Ammonia channel 著者 Laganowsky, A, Reading, E, Allison, T.M, Robinson, C.V. 登録日 2013-11-04 公開日 2014-06-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Membrane proteins bind lipids selectively to modulate their structure and function. Nature, 510, 2014
4NH5	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having 5'-pUU and UU-3' ends (2.55 Angstrom resolution) 分子名称: 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer 著者 Tian, Y, Simanshu, D.K, Patel, D.J. 登録日 2013-11-04 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
4NHF	Crystal structure of the soluble domain of TrwG Type IV secretion machinery from Bartonella grahamii 分子名称: CALCIUM ION, TrwG protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-11-04 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems. MBio, 6, 2015
5WOB	Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin 分子名称: IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... 著者 McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. 登録日 2017-08-01 公開日 2018-04-18 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.95 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5WSB	Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, allosteric activators AMP and Glucose 6-Phosphate 分子名称: 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... 著者 Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. 登録日 2016-12-06 公開日 2017-11-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8, 2017
5WP3	Crystal Structure of EED in complex with EB22 分子名称: EB22, Polycomb protein EED, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2017-08-03 公開日 2017-09-13 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4NL3	Crystal Structure of Listeria monocytogenes Hfq in complex with U6 RNA 分子名称: 5'-R(*UP*UP*UP*UP*UP*U)-3', Protein hfq 著者 Kovach, A.R, Brennan, R.G. 登録日 2013-11-13 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. Rna, 20, 2014
4NMA	Crystal structure of proline utilization A (PutA) from Geobacter sulfurreducens PCA in complex with L-tetrahydro-2-furoic acid 分子名称: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, Proline dehydrogenase and Delta-1-pyrroline-5-carboxylate dehydrogenase, ... 著者 Singh, H, Tanner, J.J. 登録日 2013-11-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc.Natl.Acad.Sci.USA, 111, 2014
4NLW	Poliovirus Polymerase - G289A/C290I Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
5WTW	Hepatitis B virus core protein Y132A mutant in P 41 21 2 Space Group 分子名称: CHLORIDE ION, Core protein 著者 Zhou, Z, Xu, Z.H. 登録日 2016-12-15 公開日 2017-02-22 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.623 Å) 主引用文献 Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
4NME	Crystal structure of proline utilization A (PutA) from Geobacter sulfurreducens PCA inactivated by N-propargylglycine 分子名称: 1,2-ETHANEDIOL, N-propargylglycine-modified flavin adenine dinucleotide, Proline dehydrogenase and Delta-1-pyrroline-5-carboxylate dehydrogenase 著者 Singh, H, Tanner, J.J. 登録日 2013-11-14 公開日 2014-02-19 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.088 Å) 主引用文献 Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc.Natl.Acad.Sci.USA, 111, 2014
5WU3	Crystal structure of human Tut1 bound with MgUTP, form II 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... 著者 Yamashita, S, Tomita, K. 登録日 2016-12-16 公開日 2017-05-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.703 Å) 主引用文献 Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
4NR3	Crystal Structure of a human Mms2/Ubc13 L121G mutant 分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 著者 Hodge, C.D, Edwards, R.A, Glover, J.N.M. 登録日 2013-11-26 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes. J.Am.Chem.Soc., 136, 2014
5W9E	Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-186 分子名称: 1-tert-butyl-3-[(3-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R. 登録日 2017-06-23 公開日 2017-08-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-186 To be published
5WUK	Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound 分子名称: GLYCEROL, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Chen, Z. 登録日 2016-12-19 公開日 2017-05-03 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522, 2017
4NE2	Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae 分子名称: (R)-N-(3-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Hughes, S.J, Antoshchenko, T, Kim, K.P, Smil, D, Park, H.W. 登録日 2013-10-28 公開日 2014-02-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus. Proteins, 82, 2014
4NCA	Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+ 分子名称: 5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ... 著者 Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. 登録日 2013-10-24 公開日 2014-01-15 最終更新日 2025-02-12 実験手法 X-RAY DIFFRACTION (2.489 Å) 主引用文献 Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
5WVX	Crystal Structure of bifunctional Kunitz type Trypsin /amylase inhibitor (AMTIN) from the tubers of Alocasia macrorrhiza 分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose, CITRIC ACID, Trypsin/chymotrypsin inhibitor 著者 Palayam, M, Radhakrishnan, M, Lakshminarayanan, K, Balu, K.E, Ganapathy, J, Krishnasamy, G. 登録日 2016-12-29 公開日 2018-06-13 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.003 Å) 主引用文献 Structural insights into a multifunctional inhibitor, 'AMTIN' from tubers of Alocasia macrorrhizos and its possible role in dengue protease (NS2B-NS3) inhibition. Int. J. Biol. Macromol., 113, 2018
5WCI	Human MYST histone acetyltransferase 1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Histone acetyltransferase KAT8, ... 著者 Dong, A, Zeng, H, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Zheng, Y.G, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2017-06-30 公開日 2017-07-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Human MYST histone acetyltransferase 1 to be published
5WCJ	Crystal Structure of Human Methyltransferase-like protein 13 in complex with SAH 分子名称: Methyltransferase-like protein 13, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION 著者 Halabelian, L, Loppnau, P, Seitova, A, Hutchinson, A, Hunt, B, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2017-06-30 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nat Commun, 9, 2018
4NGC	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having UA-3' ends (2.1 Angstrom resolution) 分子名称: 5'-R(*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*A)-3', Endoribonuclease Dicer 著者 Simanshu, D.K, Tian, Y, Patel, D.J. 登録日 2013-11-01 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.104 Å) 主引用文献 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
5WCX	Streptococcus pyogenes phosphoglycerol transferase GacH in complex with sn-glycerol-1-phosphate, crystal form 1 分子名称: CALCIUM ION, MANGANESE (II) ION, Phosphoglycerol transferase GacH, ... 著者 Edgar, R.J, Korotkova, N, Korotkov, K.V. 登録日 2017-07-02 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Phosphoglycerol transferase GacH from Streptococcus pyogenes To be published
4NFL	Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor NPB-T 分子名称: 1-{2-deoxy-3,5-O-[(4-nitrophenyl)(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'(3')-deoxyribonucleotidase, ... 著者 Pachl, P, Rezacova, P, Brynda, J. 登録日 2013-10-31 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.375 Å) 主引用文献 Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases. Org.Biomol.Chem., 12, 2014

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