4NFL
Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor NPB-T
Summary for 4NFL
Entry DOI | 10.2210/pdb4nfl/pdb |
Related | 4L6C 4MWO |
Descriptor | 5'(3')-deoxyribonucleotidase, mitochondrial, MAGNESIUM ION, PHOSPHATE ION, ... (8 entities in total) |
Functional Keywords | had-like, nucleotidase, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion: Q9NPB1 |
Total number of polymer chains | 1 |
Total formula weight | 25252.62 |
Authors | Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2013-10-31, release date: 2014-09-10, Last modification date: 2023-09-20) |
Primary citation | Simak, O.,Pachl, P.,Fabry, M.,Budesinsky, M.,Jandusik, T.,Hnizda, A.,Sklenickova, R.,Petrova, M.,Veverka, V.,Rezacova, P.,Brynda, J.,Rosenberg, I. Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases. Org.Biomol.Chem., 12:7971-7982, 2014 Cited by PubMed: 25178098DOI: 10.1039/c4ob01332h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.375 Å) |
Structure validation
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