4NFL
Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor NPB-T
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'(3')-deoxyribonucleotidase, mitochondrial | polymer | 201 | 23168.4 | 1 | UniProt (Q9NPB1) Pfam (PF06941) | Homo sapiens (human) | 5',3'-nucleotidase, mitochondrial, Deoxy-5'-nucleotidase 2, dNT-2 |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | 1-{2-deoxy-3,5-O-[(4-nitrophenyl)(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione | non-polymer | 455.3 | 1 | Chemie (2JW) | |||
| 5 | E (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | F, G, H, I, J... (A) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 7 | M, N, O, P, Q... (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 8 | T (A) | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A: 32 - 227 (UniProt: Q9NPB1)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | - | expression tag |
| Asn 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Ser 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23168.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2084.2 | |
| All* | Total formula weight | 25252.6 |
