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3KEJ
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BU of 3kej by Molmil
Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound
分子名称: 4-[(5-{2-[(3-fluorobenzyl)carbamoyl]pyridin-4-yl}-2H-tetrazol-2-yl)methyl]benzoic acid, CALCIUM ION, Collagenase 3, ...
著者Shieh, H.-S, Collins, B, Schnute, M.E.
登録日2009-10-26
公開日2010-11-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorg.Med.Chem.Lett., 20, 2010
7BF9
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BU of 7bf9 by Molmil
Mutant M107L of recombinant bovine beta-lactoglobulin in complex with tetracaine
分子名称: Beta-lactoglobulin, Tetracaine
著者Loch, J.I, Gotkowski, M, Lewinski, K.
登録日2021-01-01
公開日2021-01-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Interactions of new lactoglobulin variants with tetracaine: crystallographic studies of ligand binding to lactoglobulin mutants possessing single substitution in the binding pocket.
Acta Biochim.Pol., 68, 2021
5BUE
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BU of 5bue by Molmil
ERK2 complexed with N-benzylpyridone tetrahydroazaindazole
分子名称: 1-benzyl-4-[3-(pyridin-4-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1, NICKEL (II) ION
著者Bellamacina, C.R, Shu, W, Bussiere, D.E, Bagdanoff, J.T.
登録日2015-06-03
公開日2015-07-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
3KL6
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BU of 3kl6 by Molmil
Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor
分子名称: 1,2-ETHANEDIOL, 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl}piperidin-4-yl)tetrahydropyrimidin-2(1H)-one, CALCIUM ION, ...
著者Aertgeerts, K.
登録日2009-11-06
公開日2009-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.
J.Med.Chem., 53, 2010
5BUI
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BU of 5bui by Molmil
ERK2 complexed with 2-pyridiyl tetrahydroazaindazole
分子名称: 3-(4-fluorophenyl)-5-(pyridin-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine, Mitogen-activated protein kinase 1, NICKEL (II) ION
著者Bellamacina, C.R, Shu, W, Bussiere, D.E, Bagdanoff, J.T.
登録日2015-06-03
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
4LVX
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BU of 4lvx by Molmil
Structure of the THF riboswitch bound to tetrahydrobiopterin
分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, THF riboswitch
著者Trausch, J.J, Batey, R.T.
登録日2013-07-26
公開日2014-03-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate Riboswitch.
Chem.Biol., 21, 2014
3NBA
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BU of 3nba by Molmil
Phosphopantetheine Adenylyltranferase from Mycobacterium tuberculosis in complex with adenosine-5'-[(alpha,beta)-methyleno]triphosphate (AMPCPP)
分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, Phosphopantetheine adenylyltransferase
著者Wubben, T.J, Mesecar, A.D.
登録日2010-06-03
公開日2010-09-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.
J.Mol.Biol., 404, 2010
3K3B
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BU of 3k3b by Molmil
Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline
分子名称: 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者Bussiere, D.E, Bellamacina, C, Le, V.
登録日2009-10-02
公開日2009-12-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg.Med.Chem.Lett., 20, 2010
2O0U
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BU of 2o0u by Molmil
Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
分子名称: Mitogen-activated protein kinase 10, N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE
著者Rowland, P, Somers, D.
登録日2006-11-28
公開日2007-02-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg.Med.Chem.Lett., 17, 2007
7CQY
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BU of 7cqy by Molmil
Tetrathionate hydrolase from Acidithiobacillus ferrooxidans mutant - D325N
分子名称: SULFATE ION, Tetrathionate hydrolase
著者Tamada, T, Hirano, Y.
登録日2020-08-12
公開日2021-01-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.80035782 Å)
主引用文献Reaction mechanism of tetrathionate hydrolysis based on the crystal structure of tetrathionate hydrolase from Acidithiobacillus ferrooxidans.
Protein Sci., 30, 2020
3L1B
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BU of 3l1b by Molmil
Complex Structure of FXR Ligand-binding domain with a tetrahydroazepinoindole compound
分子名称: 1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morpholin-4-ylpropoxy)phenyl]carbonyl}-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Farnesoid X receptor
著者Xu, W, Lundquist, J.T.
登録日2009-12-11
公開日2010-03-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates.
J.Med.Chem., 53, 2010
4O6E
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BU of 4o6e by Molmil
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2
分子名称: Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2H-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxamide
著者Yin, J, Wang, W.
登録日2013-12-20
公開日2014-05-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg.Med.Chem.Lett., 24, 2014
3PNB
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BU of 3pnb by Molmil
Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with coenzyme A
分子名称: COENZYME A, Phosphopantetheine adenylyltransferase
著者Wubben, T.J, Mesecar, A.D.
登録日2010-11-18
公開日2011-06-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structure of Mycobacterium tuberculosisphosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation.
Acta Crystallogr.,Sect.F, 67, 2011
7ZC6
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BU of 7zc6 by Molmil
Na+ - translocating ferredoxin: NAD+ reductase (Rnf) of C. tetanomorphum
分子名称: FE (III) ION, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ...
著者Ermler, U, Vitt, S, Buckel, W.
登録日2022-03-25
公開日2022-09-28
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Purification and structural characterization of the Na + -translocating ferredoxin: NAD + reductase (Rnf) complex of Clostridium tetanomorphum.
Nat Commun, 13, 2022
5DFM
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BU of 5dfm by Molmil
Structure of Tetrahymena telomerase p19 fused to MBP
分子名称: GLYCEROL, Maltose-binding periplasmic protein,Telomerase-associated protein 19, SULFATE ION, ...
著者Chan, H, Cascio, D, Sawaya, M.R, Feigon, J.
登録日2015-08-27
公開日2015-10-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Science, 350, 2015
7BCZ
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BU of 7bcz by Molmil
Structure of the 4'-phosphopantetheinyl transferase PcpS from Pseudomonas aeruginosa
分子名称: 4'-phosphopantetheinyl transferase EntD, COENZYME A, MAGNESIUM ION, ...
著者Carivenc, C, Mourey, L, Pedelacq, J.D.
登録日2020-12-21
公開日2021-11-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Sci Rep, 11, 2021
4GVR
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BU of 4gvr by Molmil
X-ray structure of the Archaeoglobus fulgidus methenyl-tetrahydromethanopterin cyclohydrolase
分子名称: Methenyltetrahydromethanopterin cyclohydrolase
著者Upadhyay, V, Demmer, U, Warkentin, E, Moll, J, Shima, S, Ermler, U.
登録日2012-08-31
公開日2012-10-31
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structure and catalytic mechanism of N(5),N(10)-methenyl-tetrahydromethanopterin cyclohydrolase.
Biochemistry, 51, 2012
3RIK
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BU of 3rik by Molmil
The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
分子名称: (3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ...
著者Orwig, S.D, Lieberman, R.L.
登録日2011-04-13
公開日2012-03-14
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
Biochemistry, 50, 2011
3RIL
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BU of 3ril by Molmil
The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
分子名称: (3S,4R,5R,6S)-azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ...
著者Orwig, S.D, Lieberman, R.L.
登録日2011-04-13
公開日2012-03-14
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
Biochemistry, 50, 2011
5AZQ
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BU of 5azq by Molmil
Crystal structure of cyano-cobalt(III) tetradehydrocorrin in the heme pocket of horse heart myoglobin
分子名称: (1R,19R) cobalt tetradehydrocorrin, (1S,19S) cobalt tetradehydrocorrin, CYANIDE ION, ...
著者Mizohata, E, Morita, Y, Oohora, K, Inoue, T, Hayashi, T.
登録日2015-10-21
公開日2016-01-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structures and Coordination Behavior of Aqua- and Cyano-Co(III) Tetradehydrocorrins in the Heme Pocket of Myoglobin
Inorg.Chem., 55, 2016
5AZR
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Crystal structure of aqua-cobalt(III) tetradehydrocorrin in the heme pocket of horse heart myoglobin
分子名称: (1R,19R) cobalt tetradehydrocorrin, (1S,19S) cobalt tetradehydrocorrin, GLYCEROL, ...
著者Mizohata, E, Morita, Y, Oohora, K, Inoue, T, Hayashi, T.
登録日2015-10-21
公開日2016-01-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structures and Coordination Behavior of Aqua- and Cyano-Co(III) Tetradehydrocorrins in the Heme Pocket of Myoglobin
Inorg.Chem., 55, 2016
3Q96
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B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor
分子名称: (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide, Serine/threonine-protein kinase B-raf
著者Sintchak, M.D, Aertgeerts, K, Yano, J.
登録日2011-01-07
公開日2011-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors.
J.Med.Chem., 54, 2011
3AJM
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BU of 3ajm by Molmil
Crystal structure of programmed cell death 10 in complex with inositol 1,3,4,5-tetrakisphosphate
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Programmed cell death protein 10
著者Ding, J, Wang, D.C.
登録日2010-06-09
公開日2010-06-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation.
Biochem.Biophys.Res.Commun., 399, 2010
4A69
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Structure of HDAC3 bound to corepressor and inositol tetraphosphate
分子名称: ACETATE ION, D-MYO INOSITOL 1,4,5,6 TETRAKISPHOSPHATE, GLYCEROL, ...
著者Watson, P.J, Fairall, L, Santos, G.M, Schwabe, J.W.R.
登録日2011-11-01
公開日2012-01-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate.
Nature, 481, 2012
4L7J
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Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)
分子名称: 2-[(3aS,7aR)-2-amino-3a-(2,4-difluorophenyl)-3a,6,7,7a-tetrahydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl]pyridine-3-carbonitrile, ACETATE ION, Beta-secretase 1
著者Huestis, M.P, Liu, W, Volgraf, M, Purkey, H.E, Wang, W, Yu, C, Wu, P, Smith, D, Vigers, G, Dutcher, D, Geck Do, M.K, Hunt, K.W, Siu, M.
登録日2013-06-13
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1)
Tetrahedron Lett., 2013

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