2O0U
Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
Summary for 2O0U
Entry DOI | 10.2210/pdb2o0u/pdb |
Descriptor | Mitogen-activated protein kinase 10, N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE (3 entities in total) |
Functional Keywords | kinase fold, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42532.28 |
Authors | Rowland, P.,Somers, D. (deposition date: 2006-11-28, release date: 2007-02-27, Last modification date: 2023-12-27) |
Primary citation | Angell, R.M.,Atkinson, F.L.,Brown, M.J.,Chuang, T.T.,Christopher, J.A.,Cichy-Knight, M.,Dunn, A.K.,Hightower, K.E.,Malkakorpi, S.,Musgrave, J.R.,Neu, M.,Rowland, P.,Shea, R.L.,Smith, J.L.,Somers, D.O.,Thomas, S.A.,Thompson, G.,Wang, R. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Lett., 17:1296-1301, 2007 Cited by PubMed: 17194588DOI: 10.1016/j.bmcl.2006.12.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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