PDB: 1585 件ウェブページステータス検索Chemie searchBIRD

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3L10	Structure of split monoubiquitinated PCNA with ubiquitin in position one 分子名称: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. 登録日 2009-12-10 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
2BKR	NEDD8 NEDP1 complex 分子名称: NEDDYLIN, SENTRIN-SPECIFIC PROTEASE 8 著者 Shen, L.N, Liu, H, Dong, C, Xirodimas, D, Naismith, J.H, Hay, R.T. 登録日 2005-02-18 公開日 2005-09-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of Nedd8 Ubiquitin Discrimination by the Deneddylating Enzyme Nedp1 Embo J., 24, 2005
7NPI	Crystal structure of Mindy2 (C266A) in complex with Lys48-linked penta-ubiquitin (K48-Ub5) 分子名称: CHLORIDE ION, Polyubiquitin-C, SODIUM ION, ... 著者 Lange, S.M, Armstrong, L.A, Kulathu, Y. 登録日 2021-02-26 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell, 81, 2021
3LDZ	Crystal structure of human STAM1 VHS domain in complex with ubiquitin 分子名称: Signal transducing adapter molecule 1, Ubiquitin 著者 Ren, X, Hurley, J.H. 登録日 2010-01-13 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. Embo J., 29, 2010
1CMX	STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES 分子名称: PROTEIN (UBIQUITIN YUH1-UBAL) 著者 Johnston, S.C, Riddle, S.M, Cohen, R.E, Hill, C.P. 登録日 1999-05-12 公開日 1999-07-27 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for the specificity of ubiquitin C-terminal hydrolases. EMBO J., 18, 1999
1EUV	X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO. 分子名称: UBITQUTIN-LIKE PROTEIN SMT3, ULP1 PROTEASE 著者 Mossessova, E, Lima, C.D. 登録日 2000-04-17 公開日 2000-06-07 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol.Cell, 5, 2000
3UQA	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-11-19 公開日 2011-12-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
3V62	Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 分子名称: ATP-dependent DNA helicase SRS2, N-ETHYLMALEIMIDE, Proliferating cell nuclear antigen, ... 著者 Armstrong, A.A, Mohideen, F, Lima, C.D. 登録日 2011-12-18 公開日 2012-02-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature, 483, 2012
3V61	Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164 分子名称: BARIUM ION, N-ETHYLMALEIMIDE, Proliferating cell nuclear antigen, ... 著者 Armstrong, A.A, Mohideen, F, Lima, C.D. 登録日 2011-12-18 公開日 2012-02-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature, 483, 2012
3V6C	Crystal Structure of USP2 in complex with mutated ubiquitin 分子名称: CHLORIDE ION, GLYCEROL, Ubiquitin, ... 著者 Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2011-12-19 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of USP2 in complex with mutated ubiquitin To be Published
6DC6	Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin 分子名称: MAGNESIUM ION, PYROPHOSPHATE 2-, Ubiquitin, ... 著者 Lv, Z, Yuan, L, Williams, K.M, Atkison, J.H, Olsen, S.K. 登録日 2018-05-04 公開日 2018-10-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J. Biol. Chem., 293, 2018
3V60	Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164 分子名称: Proliferating cell nuclear antigen, SULFATE ION, Ubiquitin-like protein SMT3 著者 Armstrong, A.A, Mohideen, F, Lima, C.D. 登録日 2011-12-18 公開日 2012-02-29 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature, 483, 2012
3UQB	Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506 分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-11-19 公開日 2011-11-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
6DGF	Ubiquitin Variant bound to USP2 分子名称: Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ... 著者 Manczyk, N, Sicheri, F. 登録日 2018-05-17 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases. J. Mol. Biol., 431, 2019
1LM8	Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex 分子名称: ELONGIN B, ELONGIN C, Hypoxia-inducible factor 1 alpha, ... 著者 Min, J.-H, Yang, H, Ivan, M, Gertler, F, Kaelin JR, W.G, Pavletich, N.P. 登録日 2002-04-30 公開日 2002-06-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science, 296, 2002
1LQB	Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex 分子名称: Elongin B, Elongin C, Hypoxia-inducible factor 1 ALPHA, ... 著者 Hon, W.C, Wilson, M.I, Harlos, K, Claridge, T.D, Schofield, C.J, Pugh, C.W, Maxwell, P.H, Ratcliffe, P.J, Stuart, D.I, Jones, E.Y. 登録日 2002-05-09 公開日 2002-07-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature, 417, 2002
6PZV	Crystal Structure of Bovine DNMT1 RFTS domain in complex with H3K9me3 and Ubiquitin 分子名称: CITRATE ANION, DNA (cytosine-5)-methyltransferase 1, Histone H3.3, ... 著者 Ren, W, Song, J. 登録日 2019-08-01 公開日 2020-07-15 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc.Natl.Acad.Sci.USA, 117, 2020
6Q01	TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 2 分子名称: 1,2-ETHANEDIOL, BENZOIC ACID, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Krahn, J.M, Williams, R.S. 登録日 2019-08-01 公開日 2020-04-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (0.851 Å) 主引用文献 Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
4W9H	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) 分子名称: N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
8H38	Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex 分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... 著者 Hu, Y, Mao, Q, Chen, Z, Sun, L. 登録日 2022-10-08 公開日 2023-10-11 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.25 Å) 主引用文献 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8HM3	Complex of PPIase-BfUbb 分子名称: GLYCEROL, MAGNESIUM ION, Peptidylprolyl isomerase, ... 著者 Xu, J.H, Chen, Z, Gao, X. 登録日 2022-12-02 公開日 2023-11-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome. Nat Microbiol, 9, 2024
4W9E	pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4) 分子名称: (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4W9J	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-4-methylpentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 13) 分子名称: N-acetyl-L-leucyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4W9L	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15) 分子名称: N-acetyl-3-methyl-L-valyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
5L8W	Structure of USP12-UB-PRG/UAF1 分子名称: GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 12, ... 著者 Dharadhar, S, Sixma, T. 登録日 2016-06-08 公開日 2016-09-28 最終更新日 2016-11-30 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. J.Struct.Biol., 196, 2016

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