PDB: 1466 件ウェブページステータス検索Chemie searchBIRD

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3TMP	The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde 分子名称: OTU domain-containing protein 5, Polyubiquitin-C 著者 Ma, X, Yin, J, Hymowitz, S, Starovasnik, M, Cochran, A. 登録日 2011-08-31 公開日 2012-01-11 最終更新日 2012-02-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat.Struct.Mol.Biol., 19, 2012
6XAA	SARS CoV-2 PLpro in complex with ubiquitin propargylamide 分子名称: Non-structural protein 3, Ubiquitin-propargylamide, ZINC ION 著者 Klemm, T, Calleja, D.J, Richardson, L.W, Lechtenberg, B.C, Komander, D. 登録日 2020-06-04 公開日 2020-06-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39, 2020
3UF8	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-10-31 公開日 2011-11-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4W9C	pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 2) 分子名称: (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4W9D	pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methyloxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) 分子名称: (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4MSQ	Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 catalytic domain bound to ubiquitin 分子名称: 1,2-ETHANEDIOL, AMSH-like protease sst2, PHOSPHATE ION, ... 著者 Shrestha, R.K, Ronau, J.A, Das, C. 登録日 2013-09-18 公開日 2014-06-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product. Biochemistry, 53, 2014
4W9H	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) 分子名称: N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... 著者 Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
4MSM	Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin 分子名称: 1,2-ETHANEDIOL, AMSH-like protease sst2, PHOSPHATE ION, ... 著者 Shrestha, R.K, Ronau, J.A, Das, C. 登録日 2013-09-18 公開日 2014-06-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product. Biochemistry, 53, 2014
4N9F	Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex 分子名称: Core-binding factor subunit beta, Cullin-5, Transcription elongation factor B polypeptide 1, ... 著者 Guo, Y.Y, Dong, L.Y, Huang, Z.W. 登録日 2013-10-21 公開日 2014-01-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature, 505, 2014
4F8C	Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8 分子名称: 1,2-ETHANEDIOL, Cycle Inhibiting Factor, NEDD8 著者 Crow, A, Banfield, M. 登録日 2012-05-17 公開日 2012-06-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif Proc.Natl.Acad.Sci.USA, 2012
4FBJ	Structure of the Cif:Nedd8 complex - Photorhabdus luminescens Cycle Inhibiting Factor in complex with human Nedd8 分子名称: CHLORIDE ION, Hypothetical protein, NEDD8 著者 Crow, A, Banfield, M.J. 登録日 2012-05-23 公開日 2012-06-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif Proc.Natl.Acad.Sci.USA, 2012
6EI1	Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA 分子名称: GLYCEROL, MALONATE ION, Polyubiquitin-B, ... 著者 Pichlo, C, Baumann, U, Hofmann, K, Hermanns, T. 登録日 2017-09-16 公開日 2018-03-07 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (1.732 Å) 主引用文献 A family of unconventional deubiquitinases with modular chain specificity determinants. Nat Commun, 9, 2018
4FN2	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 分子名称: Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase, ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-06-19 公開日 2012-08-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4NQK	Structure of an Ubiquitin complex 分子名称: Probable ATP-dependent RNA helicase DDX58, Ubiquitin 著者 Peisley, A, Wu, B, Hur, S. 登録日 2013-11-25 公開日 2014-03-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature, 509, 2014
4FJV	Crystal Structure of Human Otubain2 and Ubiquitin Complex 分子名称: ETHANAMINE, GLYCEROL, Polyubiquitin-C, ... 著者 Altun, M, Walter, T.S, Kramer, H.B, Iphofer, A, David, Y, Komsany, A, Ternette, N, Nicholson, B, Navon, A, Stuart, D.I, Ren, J, Kessler, B.M. 登録日 2012-06-12 公開日 2013-06-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.047 Å) 主引用文献 The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages. Plos One, 10, 2015
3KVF	Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Davies, C.W, Maiti, T.K, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3KW5	Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Maiti, T.K, Boudreaux, D.A, Das, C. 登録日 2009-11-30 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3L0W	Structure of split monoubiquitinated PCNA with ubiquitin in position two 分子名称: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. 登録日 2009-12-10 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
3L10	Structure of split monoubiquitinated PCNA with ubiquitin in position one 分子名称: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. 登録日 2009-12-10 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
3LDZ	Crystal structure of human STAM1 VHS domain in complex with ubiquitin 分子名称: Signal transducing adapter molecule 1, Ubiquitin 著者 Ren, X, Hurley, J.H. 登録日 2010-01-13 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. Embo J., 29, 2010
5J26	Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant 分子名称: Tumor suppressor p53-binding protein 1, Ubiquitin Variant i53 著者 Wan, L, Canny, M, Juang, Y.C, Durocher, D, Sicheri, F. 登録日 2016-03-29 公開日 2016-12-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5047 Å) 主引用文献 A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing To Be Published
5JG6	APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C 分子名称: Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION 著者 Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A. 登録日 2016-04-19 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.0013 Å) 主引用文献 Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
1CMX	STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES 分子名称: PROTEIN (UBIQUITIN YUH1-UBAL) 著者 Johnston, S.C, Riddle, S.M, Cohen, R.E, Hill, C.P. 登録日 1999-05-12 公開日 1999-07-27 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for the specificity of ubiquitin C-terminal hydrolases. EMBO J., 18, 1999
1EUV	X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO. 分子名称: UBITQUTIN-LIKE PROTEIN SMT3, ULP1 PROTEASE 著者 Mossessova, E, Lima, C.D. 登録日 2000-04-17 公開日 2000-06-07 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol.Cell, 5, 2000
7Z76	Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Bader, G, Boettcher, J, Wolkerstorfer, B. 登録日 2022-03-15 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022

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