PDB: 48369 件ウェブページステータス検索Chemie searchBIRD

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5LTW	Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6 分子名称: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6, ... 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9D	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 分子名称: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator 著者 Stevers, L.M, Leysen, S.F.R, Ottmann, C. 登録日 2015-08-06 公開日 2016-03-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D2D	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 分子名称: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Leysen, S.F.R, Ottmann, C. 登録日 2015-08-05 公開日 2016-03-16 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A 分子名称: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN 著者 Stevers, L.M, Leysen, S.F.R, Ottmann, C. 登録日 2015-08-06 公開日 2016-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Ottmann, C. 登録日 2021-12-14 公開日 2022-05-25 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) 分子名称: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
5N10	Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform 分子名称: 14-3-3 protein beta/alpha, Cucurbit[8]uril, Estrogen receptor, ... 著者 de Vink, P.J, Ottmann, C. 登録日 2017-02-04 公開日 2017-05-24 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3. Angew. Chem. Int. Ed. Engl., 56, 2017
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin 分子名称: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
3LW1	Binary complex of 14-3-3 sigma and p53 pT387-peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... 著者 Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C. 登録日 2010-02-23 公開日 2010-03-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer Febs Lett., 584, 2010
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap 分子名称: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION 著者 Fiorillo, A, Ilari, A. 登録日 2015-05-08 公開日 2016-03-30 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
8BZH	FC-NAc stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZT	FC-NAg stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-15 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
3O8I	Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment 分子名称: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one 著者 Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. 登録日 2010-08-03 公開日 2010-09-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
5LU2	Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide 分子名称: 14-3-3 protein sigma, Heat shock protein beta-6 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
5MYC	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. 登録日 2017-01-26 公開日 2017-03-01 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.459 Å) 主引用文献 Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase 著者 Schumacher, B, Weyand, M, Ottmann, C. 登録日 2010-06-21 公開日 2010-09-15 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide 分子名称: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 著者 Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. 登録日 2017-11-17 公開日 2018-03-07 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018
5MY9	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. 登録日 2017-01-26 公開日 2017-03-01 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.327 Å) 主引用文献 Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 分子名称: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.081 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 分子名称: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
5LU1	Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide 分子名称: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017

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