PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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4GP0	The crystal structure of human fascin 1 R149A K150A R151A mutant 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ... 著者 Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. 登録日 2012-08-20 公開日 2012-11-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular mechanism of fascin function in filopodial formation. J.Biol.Chem., 288, 2013
6TNT	SUMOylated apoAPC/C with repositioned APC2 WHB domain 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Barford, D, Yatskevich, S. 登録日 2019-12-10 公開日 2021-01-13 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation. Cell Rep, 34, 2021
6XJR	Crystal Structure of KPT-185 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.941 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
5LG7	Solution NMR structure of Tryptophan to Arginine mutant of Arkadia RING domain 分子名称: E3 ubiquitin-protein ligase Arkadia, ZINC ION 著者 Birkou, M, Chasapis, C.T, Loutsidou, A.K, Bentrop, D, Lelli, M, Herrmann, T, Episkopou, V, Spyroulias, G.A. 登録日 2016-07-06 公開日 2017-06-28 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity. J. Mol. Biol., 429, 2017
7QP6	Structure of the human 48S initiation complex in open state (h48S AUG open) 分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. 登録日 2022-01-03 公開日 2022-05-11 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
6X7D	BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P 分子名称: 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4 著者 Vann, K.R, Kutateladze, T.G. 登録日 2020-05-29 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
2ONB	Human Thymidylate Synthase at low salt conditions with PDPA bound 分子名称: 1,2-ETHANEDIOL, PROPANE-1,3-DIYLBIS(PHOSPHONIC ACID), SULFATE ION, ... 著者 Lovelace, L.L, Gibson, L.M, Lebioda, L. 登録日 2007-01-23 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors Biochemistry, 46, 2007
8G7L	ATP-bound mtHsp60 V72I 分子名称: 60 kDa heat shock protein, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Ottmann, C. 登録日 2021-12-14 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
8G7M	ATP-bound mtHsp60 V72I focus 分子名称: 60 kDa heat shock protein, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
8G7O	ATP- and mtHsp10-bound mtHsp60 V72I focus 分子名称: 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
7XCT	Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex 分子名称: DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... 著者 Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. 登録日 2022-03-25 公開日 2022-04-20 最終更新日 2022-09-07 実験手法 ELECTRON MICROSCOPY (2.72 Å) 主引用文献 H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
7XCR	Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex 分子名称: DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... 著者 Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. 登録日 2022-03-25 公開日 2022-04-20 最終更新日 2022-09-07 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
7XD1	cryo-EM structure of unmodified nucleosome 分子名称: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... 著者 Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. 登録日 2022-03-26 公開日 2022-04-20 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
7R9C	Cocrystal of BRD4(D1) with N,N-dimethyl-2-[(3R)-3-(5-{2-[2-methyl-5-(propan-2-yl)phenoxy]pyrimidin-4-yl}-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl)pyrrolidin-1-yl]ethan-1-amine 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, CHLORIDE ION, ... 著者 Cui, H, Shi, K, Aihara, H, Pomerantz, W.C.K. 登録日 2021-06-29 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J.Med.Chem., 65, 2022
8G7N	ATP- and mtHsp10-bound mtHsp60 V72I 分子名称: 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
8G7J	mtHsp60 V72I apo 分子名称: 60 kDa heat shock protein, mitochondrial 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
8G7K	mtHsp60 V72I apo focus 分子名称: 60 kDa heat shock protein, mitochondrial 著者 Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. 登録日 2023-02-16 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
4IPZ	SmBz bound to Cyclophilin A 分子名称: CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A, cyclosporine SmBz-CsA 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2013-01-10 公開日 2013-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503, 2013
6XVW	Catalytic domain of human PARP-1 in complex with the inhibitor MC2050 分子名称: 1,2-ETHANEDIOL, 2-[2-(4-pyridin-2-ylpiperazin-1-yl)ethylsulfanyl]-3~{H}-quinazolin-4-one, NICKEL (II) ION, ... 著者 Pfahler, J, Steegborn, C. 登録日 2020-01-22 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. Acs Med.Chem.Lett., 11, 2020
7VCX	Human p97 single hexamer conformer II with ATPgammaS bound 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase 著者 Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. 登録日 2021-09-04 公開日 2022-03-02 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
8GL9	Co-crystal structure of caPCNA bound to AOH1160 derivative 1LE 分子名称: CHLORIDE ION, N~2~-(naphthalene-1-carbonyl)-N-(2-phenoxyphenyl)-L-alpha-glutamine, Proliferating cell nuclear antigen 著者 Jossart, J, Kenjic, N, Malkas, L.H, Hickey, R.J, Perry, J.J. 登録日 2023-03-21 公開日 2023-07-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30, 2023
8GLA	Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE 分子名称: CHLORIDE ION, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, Proliferating cell nuclear antigen 著者 Jossart, J, Perry, J.J. 登録日 2023-03-21 公開日 2023-07-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.77 Å) 主引用文献 Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30, 2023
7VCS	Human p97 double hexamer conformer II with ATPgammaS bound 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase 著者 Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. 登録日 2021-09-03 公開日 2022-03-02 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state. Cell Discov, 8, 2022
5MF0	Crystal structure of Smad4-MH1 bound to the GGCCG site. 分子名称: CHLORIDE ION, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), MH1 domain of human Smad4, ... 著者 Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. 登録日 2016-11-16 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017

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