5MF0

Crystal structure of Smad4-MH1 bound to the GGCCG site.

Summary for 5MF0

• Entry DOI: 10.2210/pdb5mf0/pdb
• Descriptor: MH1 domain of human Smad4, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), ZINC ION, ... (5 entities in total)
• Functional Keywords: smads, transcription factor, dna complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q13485
• Total number of polymer chains: 4
• Total formula weight: 40479.19

Authors

Kaczmarska, Z.,Freier, R.,Marquez, J.A.,Macias, M.J. (deposition date: 2016-11-16, release date: 2017-11-15, Last modification date: 2024-01-17)

• Primary citation: Martin-Malpartida, P.,Batet, M.,Kaczmarska, Z.,Freier, R.,Gomes, T.,Aragon, E.,Zou, Y.,Wang, Q.,Xi, Q.,Ruiz, L.,Vea, A.,Marquez, J.A.,Massague, J.,Macias, M.J.; Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.; Nat Commun, 8:2070-2070, 2017; PubMed: 29234012; DOI: 10.1038/s41467-017-02054-6

Experimental method

X-RAY DIFFRACTION (3.03 Å)