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5MF0

Crystal structure of Smad4-MH1 bound to the GGCCG site.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005667cellular_componenttranscription regulator complex
A0006355biological_processregulation of DNA-templated transcription
B0005667cellular_componenttranscription regulator complex
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 201
ChainResidue
ACYS71
ACYS115
ACYS127
AHIS132

site_idAC2
Number of Residues3
Detailsbinding site for residue CL A 202
ChainResidue
AHIS111
AASP120
ATYR133

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN B 201
ChainResidue
BCYS127
BHIS132
BCYS71
BCYS115

site_idAC4
Number of Residues3
Detailsbinding site for residue CL B 202
ChainResidue
BHIS111
BASP120
BTYR133

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS71
ACYS115
ACYS127
AHIS132
BCYS71
BCYS115
BCYS127
BHIS132

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS37
BLYS37

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS113
BLYS113

227111

PDB entries from 2024-11-06

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