6XVW

Catalytic domain of human PARP-1 in complex with the inhibitor MC2050

Summary for 6XVW

• Entry DOI: 10.2210/pdb6xvw/pdb
• Descriptor: Poly [ADP-ribose] polymerase 1, NICKEL (II) ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, dna-repair, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81030.58

Authors

Pfahler, J.,Steegborn, C. (deposition date: 2020-01-22, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Tomassi, S.,Pfahler, J.,Mautone, N.,Rovere, A.,Esposito, C.,Passeri, D.,Pellicciari, R.,Novellino, E.,Pannek, M.,Steegborn, C.,Paiardini, A.,Mai, A.,Rotili, D.; From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.; Acs Med.Chem.Lett., 11:862-868, 2020; PubMed: 32435397; DOI: 10.1021/acsmedchemlett.9b00654

Experimental method

X-RAY DIFFRACTION (2 Å)