6X7D

BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P

Summary for 6X7D

• Entry DOI: 10.2210/pdb6x7d/pdb
• Descriptor: Bromodomain-containing protein 4, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one (3 entities in total)
• Functional Keywords: brd4, pi3k, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32275.19

Authors

Vann, K.R.,Kutateladze, T.G. (deposition date: 2020-05-29, release date: 2020-08-05, Last modification date: 2023-10-18)

• Primary citation: Vann, K.R.,Pal, D.,Morales, G.A.,Burgoyne, A.M.,Durden, D.L.,Kutateladze, T.G.; Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.; Sci Rep, 10:12027-12027, 2020; PubMed: 32694708; DOI: 10.1038/s41598-020-68964-6

Experimental method

X-RAY DIFFRACTION (2.5 Å)