7UNE
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7LYX
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![BU of 7lyx by Molmil](/molmil-images/mine/7lyx) | Crystal structure of human CYP8B1 in complex with (S)-tioconazole | 分子名称: | (S)-Tioconazole, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, GLYCEROL, ... | 著者 | Liu, J, Scott, E.E. | 登録日 | 2021-03-08 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes. J.Biol.Chem., 298, 2022
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7B9P
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![BU of 7b9p by Molmil](/molmil-images/mine/7b9p) | Structure of Ribonucleotide reductase from Rhodobacter sphaeroides | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase | 著者 | Wilk, P, Feiler, C, Loderer, C, Kabinger, F. | 登録日 | 2020-12-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.646 Å) | 主引用文献 | HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase. Biochemistry, 61, 2022
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3HXC
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![BU of 3hxc by Molmil](/molmil-images/mine/3hxc) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8) | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | 登録日 | 2009-06-20 | 公開日 | 2009-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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3ATP
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![BU of 3atp by Molmil](/molmil-images/mine/3atp) | Structure of the ligand binding domain of the bacterial serine chemoreceptor Tsr with ligand | 分子名称: | Methyl-accepting chemotaxis protein I, SERINE | 著者 | Tajima, H, Sakuma, M, Homma, K, Kawagishi, I, Imada, K. | 登録日 | 2011-01-07 | 公開日 | 2011-10-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar. J.Biol.Chem., 286, 2011
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5M50
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![BU of 5m50 by Molmil](/molmil-images/mine/5m50) | Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins | 分子名称: | Calmodulin-regulated spectrin-associated protein 3, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Akhmanova, A, Moores, C.A, Baldus, M, Steinmetz, M.O, Topf, M, Roberts, A.J, Grant, B.J, Scarabelli, G, Joseph, A.-P, van Hooff, J.J.E, Houben, K, Hua, S, Luo, Y, Stangier, M.M, Jiang, K, Atherton, J. | 登録日 | 2016-10-20 | 公開日 | 2017-10-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | 主引用文献 | A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nat. Struct. Mol. Biol., 24, 2017
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7RKC
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![BU of 7rkc by Molmil](/molmil-images/mine/7rkc) | Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633 | 分子名称: | ACETATE ION, D_3_633 | 著者 | Kennedy, M.A, Stoddard, B.L, Hicks, D.R, Bera, A.K. | 登録日 | 2021-07-22 | 公開日 | 2022-05-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | De novo design of protein homodimers containing tunable symmetric protein pockets. Proc.Natl.Acad.Sci.USA, 119, 2022
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5M2Z
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![BU of 5m2z by Molmil](/molmil-images/mine/5m2z) | Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) | 分子名称: | NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. | 登録日 | 2016-10-13 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.8 Å) | 主引用文献 | Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
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7DBL
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3HX0
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![BU of 3hx0 by Molmil](/molmil-images/mine/3hx0) | ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA | 分子名称: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(*CP*GP*GP*CP*AP*AP*AP*TP*AP*CP*TP*G)-3', ... | 著者 | Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Havener, J.M, Perera, L, Krahn, J.M, Pedersen, L.C, Ramsden, D.A, Kunkel, T.A. | 登録日 | 2009-06-19 | 公開日 | 2009-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Scrunching During DNA Repair Synthesis To be Published
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7LL7
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![BU of 7ll7 by Molmil](/molmil-images/mine/7ll7) | [2]Catenane From MccJ25 Variant G12C G21C | 分子名称: | GLY-GLY-ALA-GLY-HIS-VAL-PRO-GLU-TYR-PHE, VAL-CYS-ILE-GLY-THR-PRO-ILE-SER-PHE-TYR-CYS | 著者 | Link, A.J, Schroeder, H.V. | 登録日 | 2021-02-03 | 公開日 | 2021-08-04 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nat.Chem., 13, 2021
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7D34
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![BU of 7d34 by Molmil](/molmil-images/mine/7d34) | AtClpS1-peptide complex | 分子名称: | ACETIC ACID, ALANINE, ATP-dependent Clp protease adapter protein CLPS1, ... | 著者 | Heo, J, Kim, L, Kwon, D.H, Song, H.K. | 登録日 | 2020-09-18 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.007 Å) | 主引用文献 | Structural basis for the N-degron specificity of ClpS1 from Arabidopsis thaliana. Protein Sci., 30, 2021
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5M3Z
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![BU of 5m3z by Molmil](/molmil-images/mine/5m3z) | Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine | 分子名称: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ... | 著者 | Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V. | 登録日 | 2016-10-17 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine. Biochim. Biophys. Acta, 1865, 2017
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7D72
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![BU of 7d72 by Molmil](/molmil-images/mine/7d72) | Cryo-EM structures of human GMPPA/GMPPB complex bound to GDP-Mannose | 分子名称: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION, Mannose-1-phosphate guanyltransferase alpha, ... | 著者 | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | 登録日 | 2020-10-02 | 公開日 | 2021-05-05 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28, 2021
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5M4Z
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![BU of 5m4z by Molmil](/molmil-images/mine/5m4z) | Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate | 分子名称: | GLYCEROL, Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Wilk, P, Maj, P, Jarmula, A, Dowiercial, A, Rode, W. | 登録日 | 2016-10-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.179 Å) | 主引用文献 | Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies. Int J Mol Sci, 22, 2021
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2K46
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![BU of 2k46 by Molmil](/molmil-images/mine/2k46) | Xenopus laevis malectin complexed with nigerose (Glcalpha1-3Glc) | 分子名称: | MGC80075 protein, alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose | 著者 | Schallus, T. | 登録日 | 2008-05-28 | 公開日 | 2008-08-12 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-Glycosylation Mol.Cell.Biol., 19, 2008
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3HXF
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![BU of 3hxf by Molmil](/molmil-images/mine/3hxf) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 32) | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | 登録日 | 2009-06-20 | 公開日 | 2009-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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7D73
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![BU of 7d73 by Molmil](/molmil-images/mine/7d73) | Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (State I) | 分子名称: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, GUANOSINE-5'-TRIPHOSPHATE, Mannose-1-phosphate guanyltransferase alpha, ... | 著者 | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | 登録日 | 2020-10-02 | 公開日 | 2021-05-05 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28, 2021
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7DQ7
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![BU of 7dq7 by Molmil](/molmil-images/mine/7dq7) | Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 5F5 | 分子名称: | 5F5 VH, 5F5 VL, Capsid protein VP4, ... | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q. | 登録日 | 2020-12-22 | 公開日 | 2021-05-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
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7DQ4
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![BU of 7dq4 by Molmil](/molmil-images/mine/7dq4) | Cryo-EM structure of CAR triggered Coxsackievirus B1 A-particle | 分子名称: | VP2, VP3, Virion protein 1 | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q. | 登録日 | 2020-12-22 | 公開日 | 2021-05-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
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5M4Q
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![BU of 5m4q by Molmil](/molmil-images/mine/5m4q) | Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | 登録日 | 2016-10-18 | 公開日 | 2017-07-12 | 最終更新日 | 2020-04-22 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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7REW
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![BU of 7rew by Molmil](/molmil-images/mine/7rew) | Crystal Structure of IL-13 in complex with MMAb3 Fab | 分子名称: | IL13, anti-cyno interleukin 13 Fab heavy chain, anti-cyno interleukin 13 Fab light chain | 著者 | Sudom, A, Min, X. | 登録日 | 2021-07-13 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation. J.Biol.Chem., 298, 2022
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7DNC
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![BU of 7dnc by Molmil](/molmil-images/mine/7dnc) | Crystal structure of EV71 3C proteinase in complex with a novel inhibitor | 分子名称: | 3C protease, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | 著者 | Xie, H, Su, H.X, Li, M.J, Xu, Y.C. | 登録日 | 2020-12-09 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J.Med.Chem., 65, 2022
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3ASK
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![BU of 3ask by Molmil](/molmil-images/mine/3ask) | Structure of UHRF1 in complex with histone tail | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ZINC ION | 著者 | Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. | 登録日 | 2010-12-16 | 公開日 | 2012-01-25 | 最終更新日 | 2013-06-05 | 実験手法 | X-RAY DIFFRACTION (2.904 Å) | 主引用文献 | Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
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7DPG
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![BU of 7dpg by Molmil](/molmil-images/mine/7dpg) | Cryo-EM structure of Coxsackievirus B1 empty particle | 分子名称: | VP2, VP3, Virion protein 1 | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q, Xia, N. | 登録日 | 2020-12-18 | 公開日 | 2021-05-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
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