PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

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7Z53	Structure of native leukocyte myeloperoxidase in complex with a truncated version (SPIN truncated) of the Staphyloccal Peroxidase Inhibitor SPIN from Staphylococcus aureus 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pfanzagl, V, Brito, J.A. 登録日 2022-03-07 公開日 2022-10-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 The staphylococcal inhibitory protein SPIN binds to human myeloperoxidase with picomolar affinity but only dampens halide oxidation. J.Biol.Chem., 298, 2022
8Z69	Crystal Structure of the second bromodomain of human BRD2 BD2 in complex with the inhibitor Y13195 分子名称: 1,2-ETHANEDIOL, 7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methyl-2-(2-phenyl-1H-imidazol-5-yl)furo[3,2-c]pyridin-4(5H)-one, BRD2_HUMAN, ... 著者 Li, J, Hu, Q, Xu, H, Zhao, X, Zhang, C, Zhu, R, Wu, X, Zhang, Y, Xu, Y. 登録日 2024-04-18 公開日 2024-12-11 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors. J.Med.Chem., 67, 2024
8T5I	Crystal structure of human WDR5 in complex with MR4397 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, ... 著者 Kimani, S, Dong, A, Li, F, Loppnau, P, Ackloo, S, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2023-06-13 公開日 2023-08-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human WDR5 in complex with MR4397 To be published
6E3R	Structure of human DNA polymerase beta complexed with 8OA as the template base in a 1-nucleotide gapped DNA 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-14 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
6E3V	Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-15 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
6E3W	Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-15 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
8ZMQ	Crystal Structure of the second bromodomain of human BRD4 BD2 in complex with the inhibitor Y13190 分子名称: 2-(2-(adamantan-1-yl)-4-ethyl-1H-imidazol-5-yl)-7-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one, BRD4_HUMAN, DIMETHYL SULFOXIDE, ... 著者 Li, J, Hu, Q, Xu, H, Zhao, X, Zhang, C, Zhu, R, Wu, X, Zhang, Y, Xu, Y. 登録日 2024-05-23 公開日 2024-12-11 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors. J.Med.Chem., 67, 2024
5HHI	Structure of human DNA polymerase beta Host-Guest complexed with CBZ-platinated N7-G 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*AP*GP*GP*AP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*TP*CP*CP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Lee, S, Koag, M.-C. 登録日 2016-01-11 公開日 2017-01-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.517 Å) 主引用文献 Synthesis, structure, and biological evaluation of a platinum-carbazole conjugate. Chem Biol Drug Des, 91, 2018
5DH4	PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine 分子名称: 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione, 5-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, ... 著者 Yan, Y. 登録日 2015-08-29 公開日 2016-01-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 26, 2016
6HQ7	Structure of EAL Enzyme Bd1971 - cGMP bound form 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION 著者 Lovering, A.L, Cadby, I.T. 登録日 2018-09-24 公開日 2019-07-31 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
8R3Y	Cryo EM structure of a stable LGL/aPKC Iota/Par-6 complex 分子名称: Lethal(2) giant larvae protein homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Partitioning defective 6 homolog alpha, ... 著者 Earl, C.P, Briggs, D.C, McDonald, N.Q. 登録日 2023-11-10 公開日 2024-11-20 最終更新日 2025-04-23 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl. Nat.Struct.Mol.Biol., 32, 2025
1PYJ	Solution Structure of an O6-[4-oxo-4-(3-pyridyl)butyl]guanine adduct in an 11mer DNA duplex 分子名称: 5'-D(*CP*CP*AP*TP*AP*TP*GP*GP*CP*CP*C)-3', 5'-D*GP*GP*GP*CP*CP*AP*TP*AP*TP*GP*G)-3' 著者 Peterson, L.A, Vu, C, Hingerty, B.E, Broyde, S, Cosman, M. 登録日 2003-07-09 公開日 2004-04-20 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of an O6-[4-oxo-4-(3-pyridyl)butyl]guanine adduct in an 11 mer DNA duplex: evidence for formation of a base triplex. Biochemistry, 42, 2003
8U85	Structural Basis of Human NOX5 Activation 分子名称: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Cui, C, Jiang, M, Sun, J. 登録日 2023-09-15 公開日 2024-05-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of human NOX5 activation. Nat Commun, 15, 2024
8U87	Structural Basis of Human NOX5 Activation 分子名称: DODECANE, FLAVIN-ADENINE DINUCLEOTIDE, HEME B/C, ... 著者 Cui, C, Jiang, M, Sun, J. 登録日 2023-09-16 公開日 2024-05-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Structural basis of human NOX5 activation. Nat Commun, 15, 2024
8U86	Structural Basis of Human NOX5 Activation 分子名称: DECANE, DODECANE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Cui, C, Jiang, M, Sun, J. 登録日 2023-09-15 公開日 2024-05-01 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of human NOX5 activation. Nat Commun, 15, 2024
6ROA	Crystal structure of V57G mutant of human cystatin C 分子名称: Cystatin-C 著者 Orlikowska, M, Behrendt, I, Borek, D, Otwinowski, Z, Skowron, P, Szymanska, A. 登録日 2019-05-10 公開日 2019-08-07 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution. Febs J., 287, 2020
8A5L	TRIM7 PRYSPRY in complex with a 2BC peptide TIEALFQ 分子名称: 2BC peptide TIEALFQ, D(-)-TARTARIC ACID, E3 ubiquitin-protein ligase TRIM7 著者 Luptak, J. 登録日 2022-06-15 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.622 Å) 主引用文献 TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing. Viruses, 14, 2022
8A2B	EGFR kinase domain (L858R/V948R) in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide 分子名称: (2R)-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)ethanamide, Epidermal growth factor receptor 著者 Kuglstatter, A, Ehler, A. 登録日 2022-06-03 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib. J.Med.Chem., 65, 2022
8A2A	EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide (form 2) 分子名称: (2R)-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)ethanamide, Epidermal growth factor receptor, SULFATE ION 著者 Kuglstatter, A, Ehler, A. 登録日 2022-06-03 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib. J.Med.Chem., 65, 2022
6EQ9	Crystal structure of JNK3 in complex with AMP-PCP 分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Macedo, J.T, Stehle, T, Blaum, B.S. 登録日 2017-10-12 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3, 2018
4O7G	Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 40 minutes 分子名称: ASCORBIC ACID, PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, ... 著者 Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. 登録日 2013-12-24 公開日 2014-02-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.211 Å) 主引用文献 Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA, 111, 2014
1CCB	THE ASP-HIS-FE TRIAD OF CYTOCHROME C PEROXIDASE CONTROLS THE REDUCTION POTENTIAL, ELECTRONIC STRUCTURE, AND COUPLING OF THE TRYPTOPHAN FREE-RADICAL TO THE HEME 分子名称: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE 著者 Goodin, D.B, Mcree, D.E. 登録日 1993-01-04 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Asp-His-Fe triad of cytochrome c peroxidase controls the reduction potential, electronic structure, and coupling of the tryptophan free radical to the heme. Biochemistry, 32, 1993
1YHP	Solution Structure of Ca2+-free DdCAD-1 分子名称: Calcium-dependent cell adhesion molecule-1 著者 Lin, Z, Huang, H.B, Siu, C.H, Yang, D.W. 登録日 2005-01-10 公開日 2006-01-31 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion Nat.Struct.Mol.Biol., 13, 2006
5UEO	BRD4_BD2_A-1395017 分子名称: Bromodomain-containing protein 4, N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide 著者 Park, C.H. 登録日 2017-01-03 公開日 2017-06-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Complex structure of BRD4_BD2_A-1395017 To Be Published
6OVM	Crystal Structure of the Pseudomonas capeferrum Anti-sigma Regulator PupR C-terminal Cell-surface Signaling Domain in Complex with the Outer Membrane Transporter PupB N-terminal Signaling Domain (SeMet) 分子名称: Ferric-pseudobactin BN7/BN8 receptor, L(+)-TARTARIC ACID, Siderophore-interacting protein 著者 Jensen, J.L, Colbert, C.L. 登録日 2019-05-08 公開日 2020-03-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria. J.Biol.Chem., 295, 2020

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