8T5I

Crystal structure of human WDR5 in complex with MR4397

Summary for 8T5I

• Entry DOI: 10.2210/pdb8t5i/pdb
• Descriptor: WD repeat-containing protein 5, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: wd-repeat, wdr, wdr5, sgc, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70133.64

Authors

Kimani, S.,Dong, A.,Li, F.,Loppnau, P.,Ackloo, S.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-13, release date: 2023-08-09)

• Primary citation: Kimani, S.,Dong, A.,Li, F.,Loppnau, P.,Ackloo, S.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Crystal structure of human WDR5 in complex with MR4397; To be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)