8T5I
Crystal structure of human WDR5 in complex with MR4397
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | WD repeat-containing protein 5 | polymer | 312 | 34289.9 | 2 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | BMP2-induced 3-kb gene protein |
| 2 | C, H (A, B) | N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide | non-polymer | 422.5 | 2 | Chemie (ZHF) | |||
| 3 | D, E, F, J, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | G, P (A, B) | UNKNOWN ATOM OR ION | non-polymer | 2 | Chemie (UNX) | ||||
| 5 | I, O (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 436 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68579.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1553.9 | |
| All* | Total formula weight | 70133.6 |
