PDB: 8880 件ウェブページステータス検索Chemie searchBIRD

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7NFC	Cryo-EM structure of NHEJ super-complex (dimer) 分子名称: DNA (27-MER), DNA (28-MER), DNA ligase 4, ... 著者 Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. 登録日 2021-02-05 公開日 2021-08-18 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
4GMJ	Structure of human NOT1 MIF4G domain co-crystallized with CAF1 分子名称: CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 7, CHLORIDE ION, ... 著者 Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E. 登録日 2012-08-16 公開日 2012-10-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex Nucleic Acids Res., 40, 2012
8AVG	Cryo-EM structure of mouse Elp123 with bound SAM 分子名称: Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... 著者 Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. 登録日 2022-08-26 公開日 2022-12-07 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.01 Å) 主引用文献 Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
7PMK	S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) 分子名称: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ... 著者 Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. 登録日 2021-09-02 公開日 2021-11-10 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
6PY8	Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA 分子名称: DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... 著者 Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. 登録日 2019-07-29 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
8BHV	DNA-PK XLF mediated dimer bound to PAXX 分子名称: DNA (24-MER), DNA (26-MER), DNA (27-MER), ... 著者 Hardwick, S.W, Chaplin, A.K. 登録日 2022-11-01 公開日 2023-06-07 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.51 Å) 主引用文献 PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
3L8S	Human p38 MAP Kinase in Complex with CP-547632 分子名称: 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2010-01-03 公開日 2010-03-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
8CUR	Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid 分子名称: 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid, Cyclin-dependent kinase 2 著者 Tripathi, S.M, Tambo, C.S, Kiss, G, Rubin, S.M. 登録日 2022-05-17 公開日 2023-04-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chem.Biol., 18, 2023
6USJ	Structure of two nucleosomes bridged by human PARP2 分子名称: Histone H2A, Histone H2B type 1-J, Histone H3.1, ... 著者 Gaullier, G, Bowerman, S, Luger, K. 登録日 2019-10-27 公開日 2020-10-14 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (10.5 Å) 主引用文献 Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1. Plos One, 15, 2020
4E6C	p38a-perifosine Complex 分子名称: (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate, Mitogen-activated protein kinase 14 著者 Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. 登録日 2012-03-15 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
4E8A	The crystal structure of p38a MAP kinase in complex with PIA24 分子名称: (1R,2S,3R,4S,6S)-6-(cyclohexylmethoxy)-2,3,4-trihydroxycyclohexyl (2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 著者 Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. 登録日 2012-03-20 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
4E5A	The W197A mutant of p38a MAP kinase 分子名称: Mitogen-activated protein kinase 14 著者 Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. 登録日 2012-03-14 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
8QFC	UFL1 E3 ligase bound 60S ribosome 分子名称: 60S ribosomal protein L10a, CDK5 regulatory subunit-associated protein 3, DDRGK domain-containing protein 1, ... 著者 Makhlouf, L, Zeqiraj, E, Kulathu, Y. 登録日 2023-09-04 公開日 2024-02-21 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature, 627, 2024
8TWA	Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, ... 著者 Yuan, Z, Georgescu, R, O'Donnell, M, Li, H. 登録日 2023-08-20 公開日 2024-09-04 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Science, 385, 2024
7JTO	Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB 分子名称: 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... 著者 Kottur, J, Jain, R, Aggarwal, A.K. 登録日 2020-08-18 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
7JTP	Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB 分子名称: Elongin-B, Elongin-C, GLYCEROL, ... 著者 Kottur, J, Jain, R, Aggarwal, A.K. 登録日 2020-08-18 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
4F9Y	Human P38 alpha MAPK In Complex With a Novel and Selective Small Molecule Inhibitor 分子名称: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... 著者 Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. 登録日 2012-05-21 公開日 2013-06-05 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One, 8, 2013
4F9W	Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor 分子名称: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, ACETATE ION, BETA-MERCAPTOETHANOL, ... 著者 Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. 登録日 2012-05-21 公開日 2013-06-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One, 8, 2013
4FA2	Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063 分子名称: 1,2-ETHANEDIOL, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, BETA-MERCAPTOETHANOL, ... 著者 Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. 登録日 2012-05-21 公開日 2013-06-05 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One, 8, 2013
7NFE	Cryo-EM structure of NHEJ super-complex (monomer) 分子名称: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... 著者 Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. 登録日 2021-02-06 公開日 2021-08-18 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.29 Å) 主引用文献 Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
7W1M	Cryo-EM structure of human cohesin-CTCF-DNA complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... 著者 Shi, Z.B, Bai, X.C, Yu, H. 登録日 2021-11-19 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
7F5S	human delta-METTL18 60S ribosome 分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Takahashi, M, Kashiwagi, K, Ito, T. 登録日 2021-06-22 公開日 2022-06-22 実験手法 ELECTRON MICROSCOPY (2.72 Å) 主引用文献 METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife, 11, 2022
3LHJ	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor. 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide 著者 Mohr, C, Jordan, S. 登録日 2010-01-22 公開日 2010-04-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J.Med.Chem., 53, 2010
8GUJ	Bre1-nucleosome complex (Model II) 分子名称: DNA (147-mer), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ... 著者 Onishi, S, Sato, K, Hamada, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of the human Bre1 complex bound to the nucleosome. Nat Commun, 15, 2024
4FI1	Crystal structure of scCK2 alpha in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, MAGNESIUM ION, ... 著者 Liu, H, Wang, H, Teng, M, Li, X. 登録日 2012-06-07 公開日 2013-06-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal structure of scCK2 alpha in complex with ATP To be Published

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