4F9Y
Human P38 alpha MAPK In Complex With a Novel and Selective Small Molecule Inhibitor
Summary for 4F9Y
Entry DOI | 10.2210/pdb4f9y/pdb |
Related | 4EWQ 4F9W 4FA2 |
Descriptor | Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine, ... (6 entities in total) |
Functional Keywords | protein kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 45023.18 |
Authors | Grum-Tokars, V.L.,Minasov, G.,Anderson, W.F.,Watterson, D.M. (deposition date: 2012-05-21, release date: 2013-06-05, Last modification date: 2020-01-01) |
Primary citation | Watterson, D.M.,Grum-Tokars, V.L.,Roy, S.M.,Schavocky, J.P.,Bradaric, B.D.,Bachstetter, A.D.,Xing, B.,Dimayuga, E.,Saeed, F.,Zhang, H.,Staniszewski, A.,Pelletier, J.C.,Minasov, G.,Anderson, W.F.,Arancio, O.,Van Eldik, L.J. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One, 8:e66226-e66226, 2013 Cited by PubMed: 23840427DOI: 10.1371/journal.pone.0066226 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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