4F9W

Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor

Summary for 4F9W

Entry DOI	10.2210/pdb4f9w/pdb
Related	4EWQ 4F9Y 4FA2
Descriptor	Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, N,N-dimethyl-6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-amine, ... (8 entities in total)
Functional Keywords	protein kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45055.48
Authors	Grum-Tokars, V.L.,Minasov, G.,Anderson, W.F.,Watterson, D.M. (deposition date: 2012-05-21, release date: 2013-06-05, Last modification date: 2023-09-13)
Primary citation	Watterson, D.M.,Grum-Tokars, V.L.,Roy, S.M.,Schavocky, J.P.,Bradaric, B.D.,Bachstetter, A.D.,Xing, B.,Dimayuga, E.,Saeed, F.,Zhang, H.,Staniszewski, A.,Pelletier, J.C.,Minasov, G.,Anderson, W.F.,Arancio, O.,Van Eldik, L.J. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One, 8:e66226-e66226, 2013 Cited by PubMed: 23840427 DOI: 10.1371/journal.pone.0066226 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation