6SBU
| X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3) | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid, L-lactate dehydrogenase A chain | 著者 | Friberg, A, Puetter, V, Nguyen, D, Rehwinkel, H. | 登録日 | 2019-07-22 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A. Acs Omega, 5, 2020
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8FUZ
| Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | O'Neill, A.G, Kollman, J.M. | 登録日 | 2023-01-18 | 公開日 | 2023-04-19 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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5LW9
| Crystal structure of human JARID1B in complex with S40563a | 分子名称: | 1,2-ETHANEDIOL, 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... | 著者 | Srikannathasan, V, Le Bihan, Y.V, Szykowska, A, Johansson, C, Gileadi, C, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Oppermann, U, Huber, K. | 登録日 | 2016-09-15 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of human JARID1B in complex with S40563a to be published
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6YNF
| GAPDH purified from the supernatant of HEK293F cells: crystal form 3 of 4. | 分子名称: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Glyceraldehyde-3-phosphate dehydrogenase | 著者 | Roversi, P, Lia, A. | 登録日 | 2020-04-13 | 公開日 | 2020-05-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | 主引用文献 | Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid. Wellcome Open Res, 5, 2020
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7S3P
| BD2 domain of human BRD3 bound to Physachenolide C | 分子名称: | Bromodomain-containing protein 3, CHLORIDE ION, Physachenolide C | 著者 | Horton, N.C, Chapman, E, Sivinski, J, Zerio, C, Ghadirian, N. | 登録日 | 2021-09-07 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Physachenolide C is a Potent, Selective BET Inhibitor. J.Med.Chem., 66, 2023
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2LY9
| Solution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907F | 分子名称: | Zinc fingers and homeoboxes protein 1 | 著者 | Xu, X, Eletsky, A, Mills, J.L, Pulavarti, S.V.S.R.K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-09-14 | 公開日 | 2012-11-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of Homeobox 2 Domain from Human ZHX1 repressor, Northeast Structural Genomics Consortium (NESG) Target HR7907F To be Published
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5LPU
| Crystal structure of Annexin A2 complexed with S100A4 | 分子名称: | Annexin A2, CALCIUM ION, GLYCEROL, ... | 著者 | Ecsedi, P, Gogl, G, Kiss, B, Nyitray, L. | 登録日 | 2016-08-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding. Structure, 25, 2017
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6Y9Z
| Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,9) | 分子名称: | Gag-Pol polyprotein, Peptidyl-prolyl cis-trans isomerase A | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | 登録日 | 2020-03-10 | 公開日 | 2020-08-19 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nat.Struct.Mol.Biol., 27, 2020
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5M24
| RARg mutant-S371E | 分子名称: | (9cis)-retinoic acid, CHLORIDE ION, DODECYL-ALPHA-D-MALTOSIDE, ... | 著者 | Rochel, N, Sirigu, S. | 登録日 | 2016-10-11 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptor gamma. PLoS ONE, 12, 2017
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6YBV
| Structure of a human 48S translational initiation complex - eIF2-TC | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | 著者 | Brito Querido, J, Sokabe, M, Kraatz, S, Gordiyenko, Y, Skehel, M, Fraser, C, Ramakrishnan, V. | 登録日 | 2020-03-17 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of a human 48Stranslational initiation complex. Science, 369, 2020
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5M23
| Modulation of MLL1 Methyltransferase Activity | 分子名称: | 4-[(~{E})-[4-[[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-pentanoyl]amino]propanoyl]amino]methyl]phenyl]diazenyl]-~{N}-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]benzamide, WD repeat-containing protein 5 | 著者 | Srinivasan, V. | 登録日 | 2016-10-11 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
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6SBV
| X-ray Structure of Human LDH-A with an Allosteric Inhibitor (Compound 7) | 分子名称: | L-lactate dehydrogenase A chain, ~{N}-[3-[(7-nitrodibenzofuran-2-yl)sulfonylamino]phenyl]-1-oxidanyl-cyclopropane-1-carboxamide | 著者 | Friberg, A, Puetter, V, Nguyen, D, Rehwinkel, H. | 登録日 | 2019-07-22 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A. Acs Omega, 5, 2020
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7UTJ
| Cryogenic electron microscopy 3D map of F-actin bound by human dimeric alpha-catenin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Rangarajan, E.S, Smith, E.W, Izard, T. | 登録日 | 2022-04-27 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Distinct inter-domain interactions of dimeric versus monomeric alpha-catenin link cell junctions to filaments. Commun Biol, 6, 2023
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6SAH
| Crystal Structure of BRD4(1) bound to inhibitor BUX5 (11) | 分子名称: | Bromodomain-containing protein 4, ~{N}-(2-methoxy-5-piperidin-1-ylsulfonyl-phenyl)-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide | 著者 | Huegle, M. | 登録日 | 2019-07-16 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63, 2020
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5LG0
| Solution NMR structure of Tryptophan to Alanine mutant of Arkadia RING domain. | 分子名称: | E3 ubiquitin-protein ligase Arkadia, ZINC ION | 著者 | Birkou, M, Chasapis, C.T, Loutsidou, A.K, Bentrop, D, Lelli, M, Herrmann, T, Episkopou, V, Spyroulias, G.A. | 登録日 | 2016-07-05 | 公開日 | 2017-06-28 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity. J. Mol. Biol., 429, 2017
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6SA3
| Crystal Structure of BRD4(1) bound to inhibitor BUX4 (13) | 分子名称: | Bromodomain-containing protein 4, ~{N}-[2-methoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide | 著者 | Huegle, M. | 登録日 | 2019-07-16 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63, 2020
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4HRH
| Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide | 分子名称: | Helicase-like transcription factor, Protein S100-A10, Annexin A2, ... | 著者 | Gao, P, Patel, D.J. | 登録日 | 2012-10-27 | 公開日 | 2013-03-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | 主引用文献 | SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.), 152, 2013
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2MQO
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2MQL
| Structural Investigation of hnRNP L | 分子名称: | Protein Hnrnpl | 著者 | Blatter, M, Allain, F. | 登録日 | 2014-06-24 | 公開日 | 2015-05-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
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7PPJ
| human SLFN5 | 分子名称: | Schlafen family member 5, ZINC ION | 著者 | Lammens, K, Metzner, F.J. | 登録日 | 2021-09-14 | 公開日 | 2022-01-26 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 50, 2022
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4HRG
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6SH7
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7V0E
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4HXN
| Brd4 Bromodomain 1 complex with 4-(2-FLUOROPHENYL)-1,3-THIAZOL-2(3H)-ONE inhibitor | 分子名称: | 4-(2-fluorophenyl)-1,3-thiazol-2(3H)-one, Bromodomain-containing protein 4 | 著者 | Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. | 登録日 | 2012-11-12 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem., 56, 2013
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7Q3Z
| DNA/RNA binding protein | 分子名称: | SODIUM ION, Schlafen family member 5, ZINC ION | 著者 | Huber, E, Lammens, K. | 登録日 | 2021-10-29 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 50, 2022
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