7S3P
BD2 domain of human BRD3 bound to Physachenolide C
Summary for 7S3P
| Entry DOI | 10.2210/pdb7s3p/pdb |
| Descriptor | Bromodomain-containing protein 3, Physachenolide C, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | inhibitor, bromodomain, epigenetics, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 11 |
| Total formula weight | 150833.80 |
| Authors | Horton, N.C.,Chapman, E.,Sivinski, J.,Zerio, C.,Ghadirian, N. (deposition date: 2021-09-07, release date: 2023-01-11, Last modification date: 2023-10-25) |
| Primary citation | Zerio, C.J.,Sivinski, J.,Wijeratne, E.M.K.,Xu, Y.M.,Ngo, D.T.,Ambrose, A.J.,Villa-Celis, L.,Ghadirian, N.,Clarkson, M.W.,Zhang, D.D.,Horton, N.C.,Gunatilaka, A.A.L.,Fromme, R.,Chapman, E. Physachenolide C is a Potent, Selective BET Inhibitor. J.Med.Chem., 66:913-933, 2023 Cited by PubMed: 36577036DOI: 10.1021/acs.jmedchem.2c01770 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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