PDB: 424 件ウェブページステータス検索Chemie searchBIRD

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9B5K	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 1 map and model from cluster 1 (Ub(A)/ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
3L1Z	Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme 分子名称: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3 著者 Benirschke, R, Thompson, J.R, Mer, G. 登録日 2009-12-14 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4. Structure, 18, 2010
6ZHU	Yeast Uba1 in complex with Ubc3 and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ubiquitin-activating enzyme E1 1, ... 著者 Misra, M, Schindelin, H. 登録日 2020-06-23 公開日 2022-01-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system To Be Published
9B5O	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 10 map and model from consensus 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
6W9D	RNF12 RING domain in complex with a Ube2d2~Ub conjugate 分子名称: E3 ubiquitin-protein ligase RLIM, IODIDE ION, Ubiquitin, ... 著者 Middleton, A.J, Day, C.L. 登録日 2020-03-22 公開日 2020-05-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains. J.Mol.Biol., 432, 2020
8SE9	Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2) 分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... 著者 Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. 登録日 2023-04-08 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
8SMX	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 2) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8SMY	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 3) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8SMZ	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (Class 4) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8SN0	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 5) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
5ZBU	Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub 分子名称: E3 ubiquitin-protein ligase RNF13, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... 著者 Datta, A.B, Sarkar, S. 登録日 2018-02-12 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub To Be Published
8BTL	Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 分子名称: Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... 著者 Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. 登録日 2022-11-29 公開日 2023-12-13 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat.Struct.Mol.Biol., 31, 2024
8UPF	Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-10-22 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
7W75	Crystal structure of the K. lactis Bre1 RBD in complex with Rad6, crystal form I 分子名称: E3 ubiquitin-protein ligase BRE1, Ubiquitin-conjugating enzyme E2 2 著者 Shi, M, Zhao, J, Xiang, S. 登録日 2021-12-03 公開日 2023-03-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for the Rad6 activation by the Bre1 N-terminal domain. Elife, 12, 2023
8E2K	Cryo-EM structure of BIRC6/HtrA2-S306A 分子名称: Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial 著者 Hunkeler, M, Fischer, E.S. 登録日 2022-08-15 公開日 2023-02-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379, 2023
9B55	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 1 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
4BWF	Pex4p-Pex22p disulphide bond mutant 分子名称: 1,2-ETHANEDIOL, PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA 著者 Williams, C, van den Berg, M, Stanley, W.A, Wilmanns, M, Distel, B. 登録日 2013-07-01 公開日 2013-07-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 A Disulphide Bond in the E2 Enzyme Pex4P Modulates Ubiquitin-Conjugating Activity Sci.Rep., 3, 2013
8SEB	Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex 分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... 著者 Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. 登録日 2023-04-08 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
5UDH	HHARI/ARIH1-UBCH7~Ubiquitin 分子名称: E3 ubiquitin-protein ligase ARIH1, Ubiquitin C variant, Ubiquitin-conjugating enzyme E2 L3, ... 著者 Miller, D.J, Schulman, B.A. 登録日 2016-12-27 公開日 2017-06-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1. Structure, 25, 2017
2Y9P	Pex4p-Pex22p mutant II structure 分子名称: PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA 著者 Williams, C, van den Berg, M, Panjikar, S, Distel, B, Wilmanns, M. 登録日 2011-02-16 公開日 2012-02-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Pex4P-Pex22P Structure To be Published
3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 分子名称: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 著者 Diao, J, Lin, D.Y, Chen, J. 登録日 2011-07-15 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
7YW1	crystal structure of UBE2O 分子名称: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 著者 Fu, Z, Zhu, W, Huang, H. 登録日 2022-08-20 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 crystal structure of UBE2O To Be Published
7LYB	Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c 分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. 登録日 2021-03-06 公開日 2021-07-28 最終更新日 2021-09-01 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
4R8P	Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle 分子名称: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... 著者 McGinty, R.K, Henrici, R.C, Tan, S. 登録日 2014-09-02 公開日 2014-11-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2846 Å) 主引用文献 Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514, 2014
4DDG	Crystal structure of human OTUB1/UbcH5b~Ub/Ub 分子名称: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 著者 Juang, Y.C, Sanches, M, Sicheri, F. 登録日 2012-01-18 公開日 2012-02-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2987 Å) 主引用文献 OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function. Mol.Cell, 45, 2012

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