7KY0
 
 | | Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020 | | 分子名称: | (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one, Epidermal growth factor receptor | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2020-12-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase.
Chemmedchem, 2024
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7ARX
 | | Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1 | | 分子名称: | DI(HYDROXYETHYL)ETHER, Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor | | 著者 | Durvanger, Z, Harmat, V, Dobo, J, Megyeri, M. | | 登録日 | 2020-10-26 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.
Acs Chem.Biol., 17, 2022
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7T8S
 | | Light Harvesting complex phycoerythrin PE 566, from the cryptophyte Cryptomonas pyrenoidifera | | 分子名称: | Bilin 584 (doubly linked), Bilin 584 (single linked), Bilin 618 (single linked), ... | | 著者 | Michie, K.A, Harrop, S.J, Rathbone, H.W, Wilk, K.E, Curmi, P.M.G. | | 登録日 | 2021-12-17 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular structures reveal the origin of spectral variation in cryptophyte light harvesting antenna proteins.
Protein Sci., 32, 2023
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7EWK
 | | Barley photosystem I-LHCI-Lhca6 supercomplex | | 分子名称: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | | 著者 | Wang, W.D, Shen, L, Tang, K, Han, G.Y, Zhang, X, Shen, J.R. | | 登録日 | 2021-05-25 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare.
Nature, 601, 2022
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7Q7T
 | | Crystal structure of human BCL6 BTB domain in complex with compound 7 | | 分子名称: | 1,2-ETHANEDIOL, 2-chloranyl-4-[[(2S)-2,7-dimethyl-5,6-bis(oxidanylidene)-2,3-dihydro-1H-[1,4]oxazepino[6,5-c]quinolin-10-yl]amino]pyridine-3-carbonitrile, ALA-TRP-VAL-ILE-PRO-ALA, ... | | 著者 | Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2021-11-09 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.
J.Med.Chem., 65, 2022
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7AX3
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7QK0
 | | Crystal structure of human BCL6 BTB domain in complex with compound 12a | | 分子名称: | (2~{S})-10-[[5-chloranyl-2-[(3~{S},5~{R})-3-methyl-5-oxidanyl-piperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, ... | | 著者 | Gunnell, E.A, Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2021-12-17 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo .
J.Med.Chem., 65, 2022
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2XZ0
 | | The Structure of the 2:1 (Partially Occupied) Complex Between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acyl Carrier Protein. | | 分子名称: | 1,2-ETHANEDIOL, ACYL CARRIER PROTEIN 1, CHLOROPLASTIC, ... | | 著者 | Moche, M, Guy, J.E, Whittle, E, Lengqvist, J, Shanklin, J, Lindqvist, Y. | | 登録日 | 2010-11-22 | | 公開日 | 2011-09-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Remote Control of Regioselectivity in Acyl-Acyl Carrier Protein-Desaturases.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5LCT
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2N03
 | | Solution NMR Structure plectin repeat domain 6 (4403-4606) of Plectin from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR6354E | | 分子名称: | Plectin | | 著者 | Pulavarti, S, Eletsky, A, Huang, Y, Janjua, H, Xiao, R, Acton, T, Everett, J, Montelione, G, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2015-03-04 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR Structure plectin repeat domain 6 (4403-4606) of Plectin from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR6354E
To be Published
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7L1T
 | | Crystal structure of human holo SepSecS | | 分子名称: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, O-phosphoseryl-tRNA(Sec) selenium transferase, PHOSPHATE ION | | 著者 | Puppala, A, Castillo Suchkou, J, Simonovic, M. | | 登録日 | 2020-12-15 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans.
Nucleic Acids Res., 2023
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5LFY
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7QPX
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7EZG
 | | The structure of the human METTL6 enzyme in complex with SAH | | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA N(3)-methylcytidine methyltransferase METTL6 | | 著者 | Xie, W, Chen, R, Zhou, J, Liu, L. | | 登録日 | 2021-06-01 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human METTL6, the m 3 C methyltransferase.
Commun Biol, 4, 2021
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7QV6
 | | Amyloid fibril from the antimicrobial peptide aurein 3.3 | | 分子名称: | Aurein-3.3 | | 著者 | Buecker, R, Seuring, C, Cazey, C, Veith, K, Garcia-Alai, M, Gruenewald, K, Landau, M. | | 登録日 | 2022-01-19 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | The Cryo-EM structures of two amphibian antimicrobial cross-beta amyloid fibrils.
Nat Commun, 13, 2022
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7KQL
 | | Anti-Tim3 antibody Fab complex | | 分子名称: | GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ... | | 著者 | Deng, X.A, West, S.M, Strop, P. | | 登録日 | 2020-11-16 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Tim-3 mediates T cell trogocytosis to limit antitumor immunity.
J.Clin.Invest., 132, 2022
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7QV5
 | | Amyloid fibril from the antimicrobial peptide uperin 3.5 | | 分子名称: | Uperin-3.5 | | 著者 | Buecker, R, Seuring, C, Cazey, C, Veith, K, Garcia-Alai, M, Gruenewald, K, Landau, M. | | 登録日 | 2022-01-19 | | 公開日 | 2022-06-29 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The Cryo-EM structures of two amphibian antimicrobial cross-beta amyloid fibrils.
Nat Commun, 13, 2022
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7F1E
 | | Structure of METTL6 bound with SAM | | 分子名称: | S-ADENOSYLMETHIONINE, tRNA N(3)-methylcytidine methyltransferase METTL6 | | 著者 | Li, S, Liao, S, Xu, C. | | 登録日 | 2021-06-09 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.589 Å) | | 主引用文献 | Structural basis for METTL6-mediated m3C RNA methylation.
Biochem.Biophys.Res.Commun., 589, 2021
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7B3A
 | | Crystal structure of PamZ | | 分子名称: | ACETATE ION, ACETYL COENZYME *A, CHLORIDE ION, ... | | 著者 | Loll, B, Dang, T, Mainz, A, Suessmuth, R, Wahl, M.C. | | 登録日 | 2020-11-30 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Molecular basis of antibiotic self-resistance in a bee larvae pathogen.
Nat Commun, 13, 2022
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7Q69
 | | Crystal structure of Chaetomium thermophilum C30S Ahp1 in the pre-reaction state | | 分子名称: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | | 著者 | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | | 登録日 | 2021-11-05 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Embo J., 41, 2022
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7ER9
 | | Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI) | | 分子名称: | 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | | 登録日 | 2021-05-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.
J.Med.Chem., 65, 2022
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2MVW
 | | Solution structure of the TRIM19 B-box1 (B1) of human promyelocytic leukemia (PML) | | 分子名称: | Protein PML, ZINC ION | | 著者 | Huang, S, Naik, M.T, Fan, P, Wang, Y, Chang, C, Huang, T. | | 登録日 | 2014-10-17 | | 公開日 | 2014-11-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The B-box 1 dimer of human promyelocytic leukemia protein.
J.Biomol.Nmr, 60, 2014
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2IZ5
 | | FUNCTION AND STRUCTURE OF THE MOLYBDENUM COFACTOR CARRIER PROTEIN MCP FROM CHLAMYDOMONAS REINHARDTII | | 分子名称: | MOCO CARRIER PROTEIN | | 著者 | Fischer, K, Llamas, A, Tejada-Jimenez, M, Schrader, N, Kuper, J, Mendel, R.R, Fernandez, E, Schwarz, G. | | 登録日 | 2006-07-25 | | 公開日 | 2006-07-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Function and Structure of the Molybdenum Cofactor Carrier Protein from Chlamydomonas Reinhardtii.
J.Biol.Chem., 281, 2006
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7QWZ
 | | Full capsid of Saccharomyces cerevisiae virus L-BCLa | | 分子名称: | Major capsid protein | | 著者 | Grybchuk, D, Prochazkova, M, Fuzik, T, Konovalovas, A, Serva, S, Yurchenko, V, Plevka, P. | | 登録日 | 2022-01-26 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly.
Commun Biol, 5, 2022
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7KRG
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