7ARX

Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1

Summary for 7ARX

Entry DOI	10.2210/pdb7arx/pdb
Descriptor	Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	protease, inhibitor, complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	47114.96
Authors	Durvanger, Z.,Harmat, V.,Dobo, J.,Megyeri, M. (deposition date: 2020-10-26, release date: 2021-11-03, Last modification date: 2024-01-31)
Primary citation	Durvanger, Z.,Boros, E.,Nagy, Z.A.,Hegedus, R.,Megyeri, M.,Dobo, J.,Gal, P.,Schlosser, G.,Angyan, A.F.,Gaspari, Z.,Perczel, A.,Harmat, V.,Mezo, G.,Menyhard, D.K.,Pal, G. Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides. Acs Chem.Biol., 17:969-986, 2022 Cited by PubMed: 35378038 DOI: 10.1021/acschembio.2c00114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation