PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

---

3NSZ	Human CK2 catalytic domain in complex with AMPPN 分子名称: Casein kinase II subunit alpha, GLYCEROL, MAGNESIUM ION, ... 著者 Ferguson, A.D. 登録日 2010-07-02 公開日 2010-12-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural basis of CX-4945 binding to human protein kinase CK2. Febs Lett., 585, 2011
3NUN	phosphoinositide-dependent kinase-1 (PDK1) with lead compound 分子名称: 6-(2-aminopyrimidin-4-yl)-1H-indazol-3-amine, GLYCEROL, PkB-like, ... 著者 Campobasso, N, Ward, P. 登録日 2010-07-07 公開日 2011-06-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery TO BE PUBLISHED
3NX8	human cAMP dependent protein kinase in complex with phenol 分子名称: PHENOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Koester, H, Heine, A, Klebe, G. 登録日 2010-07-13 公開日 2011-07-13 最終更新日 2012-02-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Experimental and computational active site mapping as a starting point to fragment-based lead discovery. Chemmedchem, 7, 2012
3O2M	Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118) 分子名称: C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, ... 著者 Abad-Zapatero, C. 登録日 2010-07-22 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. Acs Chem.Biol., 6, 2011
4I5P	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain 分子名称: (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(1H-pyrrol-2-yl)-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 著者 Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P. 登録日 2012-11-28 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.738 Å) 主引用文献 Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
3M11	Crystal Structure of Aurora A Kinase complexed with inhibitor 分子名称: 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Serine/threonine-protein kinase 6 著者 Wu, J.S, Leou, J.S, Coumar, M.S, Hsieh, H.P, Wu, S.Y. 登録日 2010-03-03 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification J.Med.Chem., 53, 2010
4HYS	Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan 分子名称: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol 著者 Kuglstatter, A, Janson, C. 登録日 2012-11-14 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.415 Å) 主引用文献 Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. Bioorg.Med.Chem.Lett., 23, 2013
4HYU	Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan 分子名称: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[3-(methylsulfonyl)propoxy]-1H-indazol-1-yl}pyrimidin-2-yl)amino]cyclohexanol 著者 Kuglstatter, A, Ghate, M. 登録日 2012-11-14 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.152 Å) 主引用文献 Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead. Bioorg.Med.Chem.Lett., 23, 2013
4I5M	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain 分子名称: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK2 著者 Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P, Neitz, R.J, Yao, N, Lin, M, Tonn, G, Zhang, H, Bova, M.P, Ren, Z, Tam, D, Ruslim, L, Baker, J, Diep, L, Fitzgerald, K, Hoffman, J, Motter, R, Fauss, D, Tanaka, P, Dappen, M, Jagodzinski, J, Chan, W, Konradi, A.W, Latimer, L, Zhu, Y.L, Artis, D.R, Sham, H.L, Anderson, J.P, Bergeron, M. 登録日 2012-11-28 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
4I6H	Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain 分子名称: (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-[2-(1,3-thiazol-4-yl)-1H-imidazol-1-yl]-7,8-dihydropteridin-6(5H)-one, Serine/threonine-protein kinase PLK2 著者 Pan, H. 登録日 2012-11-29 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain Chemmedchem, 8, 2013
3MFS	CASK-4M CaM Kinase Domain, AMPPNP 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peripheral plasma membrane protein CASK 著者 Wahl, M.C, Mukherjee, K. 登録日 2010-04-03 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Evolution of CASK into a Mg2+-sensitive kinase. Sci.Signal., 3, 2010
4IAC	X-RAY structure of cAMP dependent protein kinase A in complex with HIGH MG2+ concentration, AMP-PCP AND pseudo-substrate peptide SP20 分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Peptide SP20, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2016-09-21 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAI	X-ray Structure of cAMP dependent protein kinase A in complex with high Ca2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CARBONATE ION, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IB3	Structure of cAMP dependent protein kinase A in complex with ADP, phosphorylated peptide pSP20, and no metal 分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-07 公開日 2013-12-11 最終更新日 2014-05-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
4HYI	X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain 分子名称: 2-(1H-indazol-1-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide, GLYCEROL, Serine/threonine-protein kinase Chk1 著者 Fischmann, T.O. 登録日 2012-11-13 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
3MPA	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding 分子名称: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-26 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding TO BE PUBLISHED
3MB7	Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR) 分子名称: Casein kinase II subunit alpha, SULFATE ION, naphtho[2,1-b:7,8-b']difuran-2,9-dicarboxylic acid 著者 Reiser, J.-B, Prudent, R, Cochet, C. 登録日 2010-03-25 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24, 2010
3MN3	An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1 分子名称: Carbon catabolite-derepressing protein kinase 著者 Rudolph, M.J, Amodeo, G.A, Tong, L. 登録日 2010-04-20 公開日 2010-09-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1. Acta Crystallogr.,Sect.F, 66, 2010
4IC8	Crystal structure of the apo ERK5 kinase domain 分子名称: Mitogen-activated protein kinase 7 著者 Gogl, G, Remenyi, A. 登録日 2012-12-10 公開日 2013-02-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J.Biol.Chem., 288, 2013
4FV4	Crystal Structure of the ERK2 complexed with EK7 分子名称: 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, GLYCEROL, Mitogen-activated protein kinase 1, ... 著者 Kang, Y.N, Stuckey, J.A, Xie, X. 登録日 2012-06-29 公開日 2012-08-29 最終更新日 2014-09-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the ERK2 complexed with EK7 TO BE PUBLISHED
3MTF	Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor 分子名称: 1,2-ETHANEDIOL, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol, Activin receptor type-1, ... 著者 Chaikuad, A, Sanvitale, C, Cooper, C, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Canning, P, Krojer, T, Vollmar, M, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) 登録日 2010-04-30 公開日 2010-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A new class of small molecule inhibitor of BMP signaling. Plos One, 8, 2013
4G3C	Crystal structure of apo murine Nf-kappaB inducing kinase (NIK) 分子名称: NF-kappa-beta-inducing kinase, SULFATE ION 著者 Hymowitz, S.G, de Leon-Boenig, G. 登録日 2012-07-13 公開日 2012-08-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
3MVJ	Human cyclic AMP-dependent protein kinase PKA inhibitor complex 分子名称: (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Pandit, J, Vajdos, F. 登録日 2010-05-04 公開日 2010-06-02 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
3M42	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor 分子名称: 2-[5-(2-methoxyethoxy)pyridin-3-yl]-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin-7-one, MAGNESIUM ION, MAP kinase-activated protein kinase 2 著者 Scheufler, C, Revesz, L, Be, C, Izaac, A, Huppertz, C, Schlapbach, A, Kroemer, M. 登録日 2010-03-10 公開日 2011-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Novel pyrrolo[2,3-f]isoquinoline based MAPKAP-K2 (MK2) inhibitors with potent in vitro and in vivo activity To be Published
4FG7	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-293 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type 1 著者 Zha, M, Zhong, C, Ou, Y, Wang, J, Han, L, Ding, J. 登録日 2012-06-04 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One, 7, 2012

<120121122123124125126127128129130131132133134135>