3MTF

Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor

Summary for 3MTF

• Entry DOI: 10.2210/pdb3mtf/pdb
• Descriptor: Activin receptor type-1, PHOSPHATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: protein kinase, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 2
• Total formula weight: 71594.96

Authors

Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Canning, P.,Krojer, T.,Vollmar, M.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-30, release date: 2010-06-23, Last modification date: 2023-11-01)

• Primary citation: Sanvitale, C.E.,Kerr, G.,Chaikuad, A.,Ramel, M.C.,Mohedas, A.H.,Reichert, S.,Wang, Y.,Triffitt, J.T.,Cuny, G.D.,Yu, P.B.,Hill, C.S.,Bullock, A.N.; A new class of small molecule inhibitor of BMP signaling.; Plos One, 8:e62721-e62721, 2013; PubMed: 23646137; DOI: 10.1371/journal.pone.0062721

Experimental method

X-RAY DIFFRACTION (2.15 Å)