Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 3 |
| Chain | Residue |
| A | HOH140 |
| A | HIS286 |
| A | LYS345 |
| A | LYS346 |
| A | HOH548 |
| A | HOH557 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 4 |
| Chain | Residue |
| A | HIS284 |
| A | HIS286 |
| A | LYS345 |
| A | GLU260 |
| A | ILE262 |
| A | GLY264 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 5 |
| Chain | Residue |
| A | PO48 |
| A | HOH42 |
| A | HOH121 |
| A | ARG380 |
| A | ASN437 |
| A | ASP438 |
| A | PRO439 |
| A | HOH525 |
| A | HOH540 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 8 |
| Chain | Residue |
| A | PO45 |
| A | HOH78 |
| A | HOH93 |
| A | LYS338 |
| A | LYS340 |
| A | THR378 |
| A | ARG380 |
| A | TYR381 |
| A | HOH609 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 500 |
| Chain | Residue |
| A | SER362 |
| A | GLN367 |
| A | ASP369 |
| A | HOH558 |
| B | SER275 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 501 |
| Chain | Residue |
| A | ARG380 |
| A | TYR432 |
| A | VAL435 |
| A | PRO436 |
| A | ASN437 |
| A | HOH595 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 7 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 9 |
| Chain | Residue |
| A | TYR432 |
| A | ASP433 |
| A | VAL434 |
| A | VAL435 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 10 |
| Chain | Residue |
| A | CYS213 |
| B | HOH30 |
| B | VAL424 |
| B | HOH504 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 11 |
| Chain | Residue |
| A | EDO12 |
| A | LYS400 |
| A | ALA488 |
| A | LEU489 |
| B | GLN363 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 12 |
| Chain | Residue |
| A | EDO11 |
| A | HIS320 |
| A | LYS400 |
| A | THR487 |
| A | ALA488 |
| A | HOH574 |
| B | HOH515 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 13 |
| Chain | Residue |
| A | ARG335 |
| A | TYR399 |
| A | HOH599 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 18 |
| Chain | Residue |
| A | LYS243 |
| A | ASN372 |
| B | LYS243 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 19 |
| Chain | Residue |
| A | HIS274 |
| A | ARG490 |
| site_id | BC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE A3F A 1 |
| Chain | Residue |
| A | ALA233 |
| A | LYS235 |
| A | GLU248 |
| A | LEU263 |
| A | LEU281 |
| A | THR283 |
| A | HIS284 |
| A | TYR285 |
| A | HIS286 |
| A | GLY289 |
| A | SER290 |
| A | ASP293 |
| A | LYS340 |
| A | ASN341 |
| A | LEU343 |
| A | ASP354 |
| A | HOH596 |
| B | ASN459 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1 |
| Chain | Residue |
| B | PO42 |
| B | EDO17 |
| B | ARG380 |
| B | ASN437 |
| B | ASP438 |
| B | PRO439 |
| B | HOH548 |
| B | HOH585 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 2 |
| Chain | Residue |
| B | LYS340 |
| B | THR378 |
| B | HOH544 |
| B | HOH549 |
| B | PO41 |
| B | HOH50 |
| B | LYS338 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 6 |
| Chain | Residue |
| B | HOH62 |
| B | HOH156 |
| B | HIS286 |
| B | LYS345 |
| B | LYS346 |
| B | HOH507 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 7 |
| Chain | Residue |
| B | GLU260 |
| B | ILE262 |
| B | GLY264 |
| B | HIS284 |
| B | HIS286 |
| B | LYS345 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 500 |
| Chain | Residue |
| B | LYS400 |
| B | THR487 |
| B | ALA488 |
| B | LEU489 |
| B | HOH553 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 8 |
| Chain | Residue |
| B | HOH101 |
| B | PHE431 |
| B | ASP433 |
| B | VAL434 |
| B | GLN453 |
| B | ARG454 |
| B | ASN456 |
| B | HOH590 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 14 |
| Chain | Residue |
| B | HOH97 |
| B | HIS259 |
| B | SER314 |
| B | HIS318 |
| B | LYS492 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 15 |
| Chain | Residue |
| A | THR249 |
| A | ASN253 |
| A | SER268 |
| B | HOH579 |
| B | HOH586 |
| B | HOH588 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 16 |
| Chain | Residue |
| A | HOH176 |
| A | SER276 |
| A | THR277 |
| B | THR254 |
| B | MET360 |
| B | ASP369 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 17 |
| Chain | Residue |
| B | PO41 |
| B | ASN437 |
| B | HOH582 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 20 |
| Chain | Residue |
| B | HIS274 |
| B | SER275 |
| B | ARG490 |
| B | LYS497 |
| B | HOH593 |
| site_id | CC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE A3F B 501 |
| Chain | Residue |
| B | VAL214 |
| B | ALA233 |
| B | LYS235 |
| B | GLU248 |
| B | LEU263 |
| B | LEU281 |
| B | THR283 |
| B | HIS284 |
| B | HIS286 |
| B | GLY289 |
| B | ASP293 |
| B | LYS340 |
| B | ASN341 |
| B | LEU343 |
| B | HOH583 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK |
| Chain | Residue | Details |
| A | VAL214-LYS235 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE332-VAL344 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
